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rs173539

From SNPedia

Orientationplus
Stabilizedplus
Make rs173539(C;C)
Make rs173539(C;T)
Make rs173539(T;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position56954132
is asnp
is mentioned by
dbSNPrs173539
ebirs173539
HLIrs173539
Exacrs173539
Varsomers173539
Maprs173539
PheGenIrs173539
hapmaprs173539
1000 genomesrs173539
hgdprs173539
ensemblrs173539
gopubmedrs173539
geneviewrs173539
scholarrs173539
googlers173539
pharmgkbrs173539
gwascentralrs173539
openSNPrs173539
23andMers173539
23andMe allrs173539
SNP Nexus

SNPshotrs173539
SNPdbers173539
MSV3drs173539
GWAS Ctlgrs173539
GMAF0.3026
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele T
P-val 4E-75
Odds Ratio 0.25 [0.21-0.29] SD increase


GWAS snp
PMID [PMID 21386085OA-icon.png]
Trait
Title A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
Risk Allele C
P-val 5E-16
Odds Ratio 0.2600 [0.20-0.32] unit increase
GWAS snp
PMID [PMID 21943158OA-icon.png]
Trait
Title Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Risk Allele T
P-val 3E-65
Odds Ratio 0.2550 [0.23-0.28] mmol/l increase

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20385819OA-icon.png] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.


GET Evidence
rs173539
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.320312
summary



[PMID 23262498] Impact of geneticfactorsondyslipidemia in HIV-infected patients starting antiretroviral therapy

GWAS snp
PMID [PMID 22916037OA-icon.png]
Trait Metabolite levels
Title Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Risk Allele
P-val 3E-70
Odds Ratio NR NR


[PMID 23675527OA-icon.png] The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.


[PMID 26061659] Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616