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rs174546

From SNPedia

Orientationplus
Stabilizedplus
Make rs174546(C;C)
Make rs174546(C;T)
Make rs174546(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position61802358
GeneFADS1
is asnp
is mentioned by
dbSNPrs174546
ebirs174546
HLIrs174546
Exacrs174546
Varsomers174546
Maprs174546
PheGenIrs174546
hapmaprs174546
1000 genomesrs174546
hgdprs174546
ensemblrs174546
gopubmedrs174546
geneviewrs174546
scholarrs174546
googlers174546
pharmgkbrs174546
gwascentralrs174546
openSNPrs174546
23andMers174546
23andMe allrs174546
SNP Nexus

SNPshotrs174546
SNPdbers174546
MSV3drs174546
GWAS Ctlgrs174546
GMAF0.3297
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060910OA-icon.png]
Trait LDL cholesterol
Title Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Risk Allele G
P-val 1E-7
Odds Ratio 0.96 [0.06-0.13] mmol/l decrease



[PMID 20484448] Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

GWAS snp
PMID [PMID 20694148OA-icon.png]
Trait
Title A genome-wide association study of the metabolic syndrome in Indian Asian men
Risk Allele A
P-val 6E-7
Odds Ratio 0.03 [0.02-0.04] mmol/l decrease
GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele T
P-val 5E-24
Odds Ratio 3.8200 None

[PMID 19148276OA-icon.png] Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.

[PMID 19798445OA-icon.png] Genetic determinants of circulating sphingolipid concentrations in European populations.

[PMID 20427696OA-icon.png] Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

[PMID 20562440OA-icon.png] FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

[PMID 20565855OA-icon.png] Genetic variation in lipid desaturases and its impact on the development of human disease.

[PMID 20691134] Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.

[PMID 21593353] FADS1 genetic variability interacts with dietary alpha-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.

[PMID 21793953] FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.


[PMID 23016130OA-icon.png] Association between Polymorphisms in the Fatty Acid Desaturase Gene Cluster and the Plasma Triacylglycerol Response to an n-3 PUFA Supplementation


GET Evidence
rs174546
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.28355
summary



[PMID 24890013OA-icon.png] Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids


[PMID 25008580OA-icon.png] Genetic Variation in FADS Has Little Effect on the Association between Dietary PUFA Intake and Cardiovascular Disease

GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele T
P-val 3E-37
Odds Ratio .05 [NR] unit decrease


[PMID 26261632OA-icon.png] Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke