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rs174547

From SNPedia

Orientationplus
Stabilizedplus
Make rs174547(C;C)
Make rs174547(C;T)
Make rs174547(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position61803311
GeneFADS1
is asnp
is mentioned by
dbSNPrs174547
ebirs174547
HLIrs174547
Exacrs174547
Varsomers174547
Maprs174547
PheGenIrs174547
hapmaprs174547
1000 genomesrs174547
hgdprs174547
ensemblrs174547
gopubmedrs174547
geneviewrs174547
scholarrs174547
googlers174547
pharmgkbrs174547
gwascentralrs174547
openSNPrs174547
23andMers174547
23andMe allrs174547
SNP Nexus

SNPshotrs174547
SNPdbers174547
MSV3drs174547
GWAS Ctlgrs174547
GMAF0.3297
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele C
P-val 2E-12
Odds Ratio 0.09 [0.05-0.13] SD decrease


GWAS snp
PMID [PMID 20037589OA-icon.png]
Trait Serum metabolites
Title A genome-wide perspective of genetic variation in human metabolism
Risk Allele T
P-val 0
Odds Ratio 36.30 [NR] % variance explained
GWAS snp
PMID [PMID 20639392OA-icon.png]
Trait Resting heart rate
Title Genome-wide association analysis identifies multiple loci related with resting heart rate
Risk Allele C
P-val 2E-9
Odds Ratio 6.20 [4.22-8.18] ms decrease


GWAS snp
PMID [PMID 21829377OA-icon.png]
Trait
Title Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium.
Risk Allele T
P-val 3E-64
Odds Ratio 0.0200 [NR] % decrease
GWAS snp
PMID [PMID 21886157OA-icon.png]
Trait
Title Human metabolic individuality in biomedical and pharmaceutical research.
Risk Allele C
P-val 9E-116
Odds Ratio 0.1780 None


[PMID 22451038OA-icon.png] Intake levels of dietary long-chain polyunsaturated fatty acids modify the association between genetic variation in FADS and LDL cholesterol

GWAS snp
PMID [PMID 22286219OA-icon.png]
Trait
Title Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
Risk Allele
P-val 0
Odds Ratio 0.5700 None

[PMID 19750004OA-icon.png] A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.

[PMID 19798445OA-icon.png] Genetic determinants of circulating sphingolipid concentrations in European populations.

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20364269] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.

[PMID 20385826OA-icon.png] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

[PMID 20565855OA-icon.png] Genetic variation in lipid desaturases and its impact on the development of human disease.

[PMID 20972250] Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.

[PMID 21347282OA-icon.png] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

[PMID 21414826] Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.


GET Evidence
rs174547
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.255499
summary



GWAS snp
PMID [PMID 22960237]
Trait Comprehensive strength and appendicular lean mass
Title Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.
Risk Allele C
P-val 2E-7
Odds Ratio NR NR


[PMID 23808484OA-icon.png] Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.

GWAS snp
PMID [PMID 24823311OA-icon.png]
Trait Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)
Title Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Risk Allele C
P-val 3E-971
Odds Ratio 1.69 [1.65-1.73] unit decrease