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rs174548

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) highest phosphatidylcholine values
(C;G) intermediate phosphatidylcholine values
(G;G) lowest phosphatidylcholine values
ReferenceGRCh38 38.1/141
Chromosome11
Position61803876
GeneFADS1
is asnp
is mentioned by
dbSNPrs174548
ebirs174548
HLIrs174548
Exacrs174548
Varsomers174548
Maprs174548
PheGenIrs174548
hapmaprs174548
1000 genomesrs174548
hgdprs174548
ensemblrs174548
gopubmedrs174548
geneviewrs174548
scholarrs174548
googlers174548
pharmgkbrs174548
gwascentralrs174548
openSNPrs174548
23andMers174548
23andMe allrs174548
SNP Nexus

SNPshotrs174548
SNPdbers174548
MSV3drs174548
GWAS Ctlgrs174548
GMAF0.3439
Max Magnitude
? (C;C) (C;G) (G;G) 28

FADS1 codes for an enzyme involved in fatty acid unsaturation and the FADS1 gene SNP rs174548 seems to explain as much as ten percent of the variance in the metabolism of some glycerophospholipids. news

A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer rs174548(G) allele was associated with decreased phosphatidylcholine values. 10.1371/journal.pgen.1000282
Rs174548 295x287.jpg
GWAS snp
PMID [PMID 19043545OA-icon.png]
Trait Serum metabolites
Title Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
Risk Allele
P-val 5E-8
Odds Ratio NR NR


GWAS snp
PMID [PMID 20864672OA-icon.png]
Trait
Title Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Risk Allele G
P-val 1E-12
Odds Ratio 0.01 [0.007-0.015] unit decrease


[PMID 22960237] Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males


GET Evidence
rs174548
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.320312
summary



GWAS snp
PMID [PMID 23303382]
Trait Hematology traits
Title Genome-wide association study of serum albumin:globulin ratio in Korean populations.
Risk Allele G
P-val 4E-8
Odds Ratio .02 [0.011-0.023] unit increase
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele C
P-val 1E-84
Odds Ratio .05 [0.043-0.055] unit increase


[PMID 25646338] Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium