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rs174570

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs174570(C;T)
Make rs174570(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position61829740
GeneFADS2
is asnp
is mentioned by
dbSNPrs174570
ebirs174570
HLIrs174570
Exacrs174570
Varsomers174570
Maprs174570
PheGenIrs174570
hapmaprs174570
1000 genomesrs174570
hgdprs174570
ensemblrs174570
gopubmedrs174570
geneviewrs174570
scholarrs174570
googlers174570
pharmgkbrs174570
gwascentralrs174570
openSNPrs174570
23andMers174570
23andMe allrs174570
SNP Nexus

SNPshotrs174570
SNPdbers174570
MSV3drs174570
GWAS Ctlgrs174570
GMAF0.2351
Max Magnitude0
? (C;C) (C;T) (T;T) 28
per the 23andMe blog, the minor allele of this SNP (T) was associated with decreased cholesterol and increased triglycerides
SNP Rarer allele LDL HDL TG
rs6544713 T +
rs2650000 A +
rs471364 C -
rs1800961 T -
rs7679 C - +
rs2967605 T -
rs2409722 T -
rs10903129 A - - -
rs6756629 A - + -
rs12670798 C + + +
rs7395662 A - + +
rs174570 T - - +
rs2271293 A - + -
rs2624265 C +
rs2167079 T +
rs9891572 T +
rs4844614 T +
rs5031002 G +
GWAS snp
PMID [PMID 19060911OA-icon.png]
Trait Cholesterol, total
Title Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Risk Allele G
P-val 2E-10
Odds Ratio 0.09 [NR] SD increase



[PMID 20484448] Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study




[PMID 19798445OA-icon.png] Genetic determinants of circulating sphingolipid concentrations in European populations.


[PMID 19944404OA-icon.png] Genomic dissection of population substructure of Han Chinese and its implication in association studies.


[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.


[PMID 20502693OA-icon.png] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.


[PMID 20565855OA-icon.png] Genetic variation in lipid desaturases and its impact on the development of human disease.


[PMID 21383846OA-icon.png] Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.

rs7115739 and rs174570 http://www.sciencemag.org/content/349/6254/1343.full Greenlandic Inuit show genetic signatures of diet and climate adaptation

GET Evidence
rs174570
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.148438
summary



GWAS snp
PMID [PMID 24647736]
Trait Glycated hemoglobin levels
Title Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Risk Allele C
P-val 2E-7
Odds Ratio .04 [0.020-0.060] unit increase