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rs1746048

From SNPedia

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Stabilizedplus
Geno Mag Summary
(C;C) 1.3 1.03 increased risk for coronary heart disease
(C;T) 1.8 0.94 decreased risk for coronary heart disease
(T;T) 2 0.85 decreased risk for coronary heart disease
ReferenceGRCh38 38.1/142
Chromosome10
Position44280376
is asnp
is mentioned by
dbSNPrs1746048
ebirs1746048
HLIrs1746048
Exacrs1746048
Varsomers1746048
Maprs1746048
PheGenIrs1746048
hapmaprs1746048
1000 genomesrs1746048
hgdprs1746048
ensemblrs1746048
gopubmedrs1746048
geneviewrs1746048
scholarrs1746048
googlers1746048
pharmgkbrs1746048
gwascentralrs1746048
openSNPrs1746048
23andMers1746048
23andMe allrs1746048
SNP Nexus

SNPshotrs1746048
SNPdbers1746048
MSV3drs1746048
GWAS Ctlgrs1746048
GMAF0.2833
Max Magnitude2
? (C;C) (C;T) (T;T) 28

23andMe blog coronary artery disease and heart attack

SNP Risk Version Effect

GWAS snp
PMID [PMID 19198609OA-icon.png]
Trait Myocardial infarction (early onset)
Title Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Risk Allele C
P-val 7E-9
Odds Ratio 1.17 [1.11-1.24]



GWAS snp
PMID [PMID 21378990OA-icon.png]
Trait
Title Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele C
P-val 3E-10
Odds Ratio 1.0900 [1.07-1.13]


[PMID 21415067OA-icon.png] The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels


[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.


[PMID 20835900OA-icon.png] Genetics of diabetes complications.


GET Evidence
rs1746048
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.367188
summary



Coronary Heart Disease


[PMID 23531450] Relationship between Chemokine (C-X-C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: Case-control study and meta-analysis


[PMID 23666823] Genetic variants on chromosome 10q11.21 are associated with ischemic stroke in the northern Chinese Han population.


[PMID 25804320] Association Between Coronary Artery Disease Genetic Variants and Subclinical Atherosclerosis: an Association Study and Meta-analysis


[PMID 26324845] Association of chemokine CXC ligand 12 gene polymorphism (rs1746048) with cardiovascular mortality in patients with rheumatoid arthritis: results from the Norfolk Arthritis Register