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rs17487223

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) 2 Higher lung cancer risk?
(T;T) 2.5 1.28x lung cancer risk
ReferenceGRCh38 38.1/141
Chromosome15
Position78631645
GeneCHRNB4
is asnp
is mentioned by
dbSNPrs17487223
ebirs17487223
HLIrs17487223
Exacrs17487223
Varsomers17487223
Maprs17487223
PheGenIrs17487223
hapmaprs17487223
1000 genomesrs17487223
hgdprs17487223
ensemblrs17487223
gopubmedrs17487223
geneviewrs17487223
scholarrs17487223
googlers17487223
pharmgkbrs17487223
gwascentralrs17487223
openSNPrs17487223
23andMers17487223
23andMe allrs17487223
SNP Nexus

SNPshotrs17487223
SNPdbers17487223
MSV3drs17487223
GWAS Ctlgrs17487223
GMAF0.2094
Max Magnitude2.5
? (C;C) (C;T) (T;T) 28
Rs17487223
PubMed [PMID 18385738]
Affy Probeset SNP_A-8440085
Affy Orientation reverse
On GW 5.0
Alleles A/B A/G
Ancestral
Population Caucasian(Europe)
Allele T
Case Freq. 0.42
Control Freq. 0.36
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.28
Disease Lung cancer (LC)


rs17487223 increases susceptibility to Lung cancer 1.28 times for carriers of the T allele [PMID 18385738]

plos Risk Factors for Age-Dependent Nicotine Addiction


[PMID 18519524OA-icon.png] Variants in nicotinic receptors and risk for nicotine dependence.


[PMID 18618000OA-icon.png] A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.


[PMID 18759969OA-icon.png] In search of causal variants: refining disease association signals using cross-population contrasts.


[PMID 19029397OA-icon.png] Nicotinic receptor gene variants influence susceptibility to heavy smoking.


[PMID 19259974OA-icon.png] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.


[PMID 19330903OA-icon.png] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.


[PMID 19443489OA-icon.png] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.


[PMID 19706762OA-icon.png] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.