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rs17611

From SNPedia

Orientationminus
Stabilizedminus
Make rs17611(A;A)
Make rs17611(A;G)
Make rs17611(G;G)
ReferenceGRCh38 38.1/141
Chromosome9
Position121006922
GeneC5
is asnp
is mentioned by
dbSNPrs17611
ebirs17611
HLIrs17611
Exacrs17611
Varsomers17611
Maprs17611
PheGenIrs17611
hapmaprs17611
1000 genomesrs17611
hgdprs17611
ensemblrs17611
gopubmedrs17611
geneviewrs17611
scholarrs17611
googlers17611
pharmgkbrs17611
gwascentralrs17611
openSNPrs17611
23andMers17611
23andMe allrs17611
SNP Nexus

SNPshotrs17611
SNPdbers17611
MSV3drs17611
GWAS Ctlgrs17611
GMAF0.4073
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 19028820] Although rs17611 was the only SNP to remain significant after multivariate analysis (odds ratio 0.585, p = 0.0037) in a study of 459 patients, ROC curve analysis did not show any contribution of this SNP to overall stroke risk.
OMIM120900
DescCOMPLEMENT COMPONENT 5; C5
Variant
Relatedalso
[PMID 19619703OA-icon.png] Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study


[PMID 19909405] Single nucleotide polymorphisms of complement component 5 and periodontitis

OMIM120900
Desc
Variant0005
Relatedalso


[PMID 21871809] Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage


[PMID 22452399] Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis


[PMID 15371359OA-icon.png] Testing for Hardy-Weinberg equilibrium in samples with related individuals.


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 17428459] Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18644651] Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection.


[PMID 18648537OA-icon.png] A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 20018035OA-icon.png] A combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data.


[PMID 21393613] Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.


GET Evidence
C5-V802I
aa_change Val802Ile
aa_change_short V802I
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.32283
summary



[PMID 23662819OA-icon.png] Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.


[PMID 25725109OA-icon.png] Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis


[PMID 26092810] Response to Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis"


[PMID 26092809] Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis"