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rs17612858(T;T)

From SNPedia

highest risk of Podoconiosis
Is agenotype
ofrs17612858
GeneHLA-DQA1
Chromosome6
Position32,652,845
mentionedby
Magnitude3
ReputeBad
Geno Mag Summary
(A;A) 0 lowest risk of Podoconiosis
(T;T) 3 highest risk of Podoconiosis

The presence of the minor allele (T) of this SNP was associated with an increased risk of susceptibility to podoconiosis substantially (odds ratio, 2.44 in the allelic model and 2.19 in the additive model). This is a neglected tropical disease which causes elephantitis when exposed to volcanic soil. [PMID 22455414]

An estimated one-fifth of Ethiopians carry the genetic variants that result in the debilitating disease. http://www.genome.gov/27558535