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rs17817449

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) ~1.7x increased obesity risk
(G;T) ~1.3x increased obesity risk
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome16
Position53779455
GeneFTO
is asnp
is mentioned by
dbSNPrs17817449
ebirs17817449
HLIrs17817449
Exacrs17817449
Varsomers17817449
Maprs17817449
PheGenIrs17817449
hapmaprs17817449
1000 genomesrs17817449
hgdprs17817449
ensemblrs17817449
gopubmedrs17817449
geneviewrs17817449
scholarrs17817449
googlers17817449
pharmgkbrs17817449
gwascentralrs17817449
openSNPrs17817449
23andMers17817449
23andMe allrs17817449
SNP Nexus

SNPshotrs17817449
SNPdbers17817449
MSV3drs17817449
GWAS Ctlgrs17817449
GMAF0.3242
Max Magnitude0
? (G;G) (G;T) (T;T) 28
Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs17817449, although this SNP is one of co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied of FTO SNPs, rs9930506. [PMID 17658951OA-icon.png]

[PMID 18316358] A study of 900+ Quebec individuals reported that rs17817449 was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).

  • Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0 %) and T-T-T (55.5 %).

[PMID 18719664] This SNP is also associated with adult obesity in Mexicans.

[PMID 18551112] rs1421085(C) and rs17817449(G) significantly associated with increased BMI. Our results suggest that FTO may be one of the worldwide obesity-risk genes.

Neighborrs8043757
Distance83


[PMID 19278366] A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies.


[PMID 19322589OA-icon.png] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study

OMIM612460
DescBODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14; BMIQ14
Variant
Relatedalso
[PMID 20717169OA-icon.png] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males

[PMID 20945952OA-icon.png] FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study

GWAS snp
PMID [PMID 21552555OA-icon.png]
Trait
Title A genome-wide association study on obesity and obesity-related traits.
Risk Allele
P-val 2E-12
Odds Ratio None None


[PMID 20945953] Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms


[PMID 22030988] FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain

[PMID 17928949] FTO polymorphisms in oceanic populations.

[PMID 18218107OA-icon.png] FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.

[PMID 18256137OA-icon.png] Regulation of Fto/Ftm gene expression in mice and humans.

[PMID 18487448OA-icon.png] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.

[PMID 18599522OA-icon.png] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.

[PMID 18647953OA-icon.png] Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

[PMID 18833210] The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.

[PMID 19265514OA-icon.png] FTO gene variation and measures of body mass in an African population.

[PMID 20080751OA-icon.png] Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

[PMID 20362563] A FTO variant and risk of acute coronary syndrome.

[PMID 20381893OA-icon.png] The genetics of obesity: FTO leads the way.

[PMID 20404173OA-icon.png] A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

[PMID 20442772OA-icon.png] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

[PMID 20502638OA-icon.png] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

[PMID 21102551OA-icon.png] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

[PMID 21317302OA-icon.png] FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.

[PMID 21318054OA-icon.png] Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents.

[PMID 21788373OA-icon.png] The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.

[PMID 21919686] Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population.

[PMID 22157232] Lack of an association between three tagging SNPs within the FTO gene and smoking behavior.

[PMID 22187296] Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.

[PMID 22614171OA-icon.png] Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.


GET Evidence
rs17817449
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.40625
summary



[PMID 23136261OA-icon.png] Fat mass and obesity gene and cognitive decline: The Atherosclerosis Risk in Communities Study


[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele T
P-val 6E-7
Odds Ratio 1.09 [1.05-1.12]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele T
P-val 6E-14
Odds Ratio 1.08 [1.05-1.1]


[PMID 22503908] Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study.


[PMID 23201545] FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.


[PMID 23771786] Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence.


[PMID 26726774] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.


[PMID 27196486] FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population.