|| Slight increase (1.4x) in risk for Graves disease
A meta-analysis including eight studies (totaling 6,976 cases and 7,089 controls) reports an association between rs179247(A) with Graves disease (odds ratio 1.4, CI: 1.353-1.495, p<0.001), and the associations were the same under dominant, recessive and co-dominant models.[PMID 27231040]
|?|| (A;A) (A;G) (G;G) ||28|
[PMID 19244275] Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease
[PMID 21124799] Thyroid Stimulating Hormone Receptor (TSHR) Intron 1 Variants Are Major Risk Factors for Graves' Disease in Three European Caucasian Cohorts
[PMID 22673349] Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population
[PMID 21642385] Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.