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rs1799724

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal risk
(C;T) 2 if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
(T;T) 2 if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
ReferenceGRCh38 38.1/141
Chromosome6
Position31574705
GeneLTA, TNF
is asnp
is mentioned by
dbSNPrs1799724
ebirs1799724
HLIrs1799724
Exacrs1799724
Varsomers1799724
Maprs1799724
PheGenIrs1799724
hapmaprs1799724
1000 genomesrs1799724
hgdprs1799724
ensemblrs1799724
gopubmedrs1799724
geneviewrs1799724
scholarrs1799724
googlers1799724
pharmgkbrs1799724
gwascentralrs1799724
openSNPrs1799724
23andMers1799724
23andMe allrs1799724
SNP Nexus

SNPshotrs1799724
SNPdbers1799724
MSV3drs1799724
GWAS Ctlgrs1799724
GMAF0.09734
Max Magnitude2
rs1799724, a SNP near the tumor necrosis factor TNF gene, was found in a study of ~500 Caucasians to be both an independent risk factor for the development of Alzheimer's disease and also a modifier of the risk for individuals carrying ApoE4 alleles. [PMID 15895461]

On its own, the rs1799724(T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of ApoE4 alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of rs1799724(T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence. [PMID 15895461]

In a Chinese study [PMID 18551993], post-menopausal women were significantly more likely to have low bone mineral density if they had

Neighborrs1041981
Distance1698
Neighborrs361525
Distance619
Neighborrs1800629
Distance549
Neighborrs1800750
Distance481
Neighborrs1799964
Distance174
Neighborrs1800630
Distance6


[PMID 19282863] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension

OMIM191160
DescTUMOR NECROSIS FACTOR; TNF
Variant
Relatedalso

news cigarette smoking and gastric cancer risk



[PMID 20357201] Association of Polymorphisms of Tumor Necrosis Factor and Tumor Protein p53 with Primary Open Angle Glaucoma: A Replication Study of Ten Genes in A Chinese Population


[PMID 21228795] Impact of LIMK1, MMP2 and TNF-? variations for intracranial aneurysm in Japanese population

? (C;C) (C;T) (T;T)
OMIM191160
Desc
Variant0005
Relatedalso


[PMID 21904873] Association of tumor necrosis factor-? (TNF-?) promoter polymorphisms with overweight/obesity in a Korean population


[PMID 21509504OA-icon.png] Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study


[PMID 12509789OA-icon.png] Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.


[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.


[PMID 16916584] Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.


[PMID 17018637] Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma.


[PMID 17062130OA-icon.png] Polymorphisms within inflammatory genes and colorectal cancer.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.


[PMID 17493155] Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.


[PMID 18196539] TNF polymorphisms and prostate cancer risk.


[PMID 18319718OA-icon.png] Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis.


[PMID 18366708OA-icon.png] SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 18635873OA-icon.png] TNF promoter polymorphisms associated with muscle phenotypes in humans.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18698679OA-icon.png] Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk.


[PMID 18709160OA-icon.png] Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18811622] Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.


[PMID 18990758OA-icon.png] Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19406964OA-icon.png] Association of genetic variants with chronic kidney disease in Japanese individuals.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 19615068OA-icon.png] The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.


[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.


[PMID 19673882OA-icon.png] A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.


[PMID 19742166OA-icon.png] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.


[PMID 19818126OA-icon.png] Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study.


[PMID 20668555OA-icon.png] Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 20952689OA-icon.png] Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma.


[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.


[PMID 22630053] Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients.


GET Evidence
rs1799724
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0546875
summary



[PMID 23086128] Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer


[PMID 23734748OA-icon.png] Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes


[PMID 23870134OA-icon.png] Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma


[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects


[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria


[PMID 24259423] Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia


[PMID 24405540] [Association of TNF-1031T/C and clinical efficacy of insulin therapy in newly diagnosed type 2 diabetics]


[PMID 22711844] SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.


[PMID 23021043] Genetics of Behcet's disease in Sardinia: two distinct extended HLA haplotypes harbour the B*51 allele in the normal population and in patients.


[PMID 23071570OA-icon.png] Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.


[PMID 24935328] Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation


[PMID 25083576OA-icon.png] Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study


[PMID 25246119] Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese


[PMID 25634985] The -308G>A Polymorphism of the TNF Gene is Associated with Proliferative Diabetic Retinopathy in Caucasian-Brazilians with Type 2 Diabetes


[PMID 25636570] Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil


[PMID 26191295OA-icon.png] CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population


[PMID 26550110OA-icon.png] The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis