|(-;-)||2||less favorable clinical outcome when on antipsychotics|
|(-;C)||2||1.3x increased adenoma recurrence risk|
In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake.[19065655?dopt=Abstract PMID 19065655]
23andMe blog Alcoholism related
- rs1799971(A;A) severe alcoholism 2x
- rs1799732(I;I) severe alcoholism 1.85x
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|qualified_impact||Insufficiently evaluated pharmacogenetic|
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