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rs1799732

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(-;-) 2 less favorable clinical outcome when on antipsychotics
(-;C) 2 1.3x increased adenoma recurrence risk
(C;C) 0 normal
ReferenceGRCh38 38.1/142
Chromosome11
Position113475529
GeneDRD2
is asnp
is mentioned by
dbSNPrs1799732
ebirs1799732
HLIrs1799732
Exacrs1799732
Varsomers1799732
Maprs1799732
PheGenIrs1799732
hapmaprs1799732
1000 genomesrs1799732
hgdprs1799732
ensemblrs1799732
gopubmedrs1799732
geneviewrs1799732
scholarrs1799732
googlers1799732
pharmgkbrs1799732
gwascentralrs1799732
openSNPrs1799732
23andMers1799732
23andMe allrs1799732
SNP Nexus

SNPshotrs1799732
SNPdbers1799732
MSV3drs1799732
GWAS Ctlgrs1799732
GMAF0.2346
Max Magnitude2
rs1799732 is a SNP in the D2 dopamine receptor gene DRD2 gene. Although dbSNP indicates the alleles as (C) or (-) (i.e. a deletion), investigators report the alleles as (C) or (T).

In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake.[19065655?dopt=Abstract PMID 19065655OA-icon.png]

23andMe blog Alcoholism related

  • rs1799971(A;A) severe alcoholism 2x
  • rs1799732(I;I) severe alcoholism 1.85x


[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution


[PMID 19547807] Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia



[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene


[PMID 20664489OA-icon.png] DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia














[PMID 21714067] Association between polymorphisms of DRD2 and DRD4 and opioid dependence: Evidence from the current studies


[PMID 17135598] No evidence for a major role of polymorphisms during bupropion treatment.


[PMID 17417059] A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate.


[PMID 17466074OA-icon.png] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.


[PMID 18077373OA-icon.png] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.


[PMID 18305461OA-icon.png] Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.


[PMID 18366720OA-icon.png] Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.


[PMID 18563706OA-icon.png] The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study.


[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.


[PMID 19285111] C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.


[PMID 19390575OA-icon.png] Lung cancer susceptibility model based on age, family history and genetic variants.


[PMID 19669131OA-icon.png] Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.


[PMID 20146828OA-icon.png] Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.


[PMID 20191112OA-icon.png] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.


[PMID 21162693OA-icon.png] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.


[PMID 21554498] Dopaminergic genes modulate response inhibition in alcohol abusing adults.


[PMID 21645585] Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype.


[PMID 22382052] A DRD2 and ANKK1 haplotype is associated with nicotine dependence.


[PMID 22574669] Dopamine receptors D1 and D2 are related to observed maternal behavior.


[PMID 22615781OA-icon.png] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study


GET Evidence
rs1799732
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.290323
summary



[PMID 22579533] Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.


[PMID 22875483] Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.


[PMID 27121382] Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model.