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rs1799884

From SNPedia

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Geno Mag Summary
(A;A) 3 2.7x increased risk for Type 2 Diabetes. Mothers have babies 54g heavier.
(A;G) 2 1.3x increased risk for Type 2 Diabetes. Mothers have babies 27g heavier.
(G;G) 2 Mothers have typical Birth-Weight babies. Slightly lower risk of Type 2 Diabetes.
ReferenceGRCh38 38.1/141
Chromosome7
Position44189469
GeneGCK
is asnp
is mentioned by
dbSNPrs1799884
ebirs1799884
HLIrs1799884
Exacrs1799884
Varsomers1799884
Maprs1799884
PheGenIrs1799884
hapmaprs1799884
1000 genomesrs1799884
hgdprs1799884
ensemblrs1799884
gopubmedrs1799884
geneviewrs1799884
scholarrs1799884
googlers1799884
pharmgkbrs1799884
gwascentralrs1799884
openSNPrs1799884
23andMers1799884
23andMe allrs1799884
SNP Nexus

SNPshotrs1799884
SNPdbers1799884
MSV3drs1799884
GWAS Ctlgrs1799884
GMAF0.1882
Max Magnitude3
? (A;A) (A;G) (G;G) 28
rs1799884, known also as the -30 SNP of the GCK gene, has been associated with type-2 diabetes.

This SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under a recessive model, the odds ratio for rs1799884(A;A) homozygotes is 2.70 (CI: 1.51-4.83, p=0.0008); under an additive model, the odds ratio is 1.34 (CI: 1.07-1.69, p=0.01). For the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]


[PMID 19241058] Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.

OMIM138079
DescGLUCOKINASE; GCK
Variant
Relatedalso
[PMID 20682688OA-icon.png] Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups

[PMID 20858683OA-icon.png] Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways

OMIM613219
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 21909109]
Trait
Title Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Risk Allele A
P-val 2E-19
Odds Ratio 0.0619 [0.049-0.075] mg/dL increase


[PMID 22716779] Relevant associations of the glucokinase regulatory protein/glucokinase gene variation with TAG concentrations in a high-cardiovascular risk population: modulation by the Mediterranean diet

[PMID 17186458OA-icon.png] A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

[PMID 17503332OA-icon.png] Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

[PMID 18332101] Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

[PMID 18498634OA-icon.png] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

[PMID 18521185OA-icon.png] Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

[PMID 18556336OA-icon.png] The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

[PMID 18689695OA-icon.png] Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

[PMID 19018513] The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

[PMID 19060907OA-icon.png] Variants in MTNR1B influence fasting glucose levels.

[PMID 19073768OA-icon.png] Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

[PMID 19368707OA-icon.png] Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.

[PMID 19533084OA-icon.png] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

[PMID 19741163OA-icon.png] Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.

[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.

[PMID 20227404] The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes.

[PMID 20628598OA-icon.png] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.

[PMID 20661421OA-icon.png] Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.

[PMID 20668700OA-icon.png] Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.

[PMID 21697023] [Fasting hyperglycaemia and polymorphism in glucokinase promoter (rs1799884)].


[PMID 23690305OA-icon.png] Genetic variants and the risk of gestational diabetes mellitus: a systematic review


[PMID 23840762OA-icon.png] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk

GWAS snp
PMID [PMID 23575436]
Trait Glycemic traits
Title New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
Risk Allele A
P-val 5E-18
Odds Ratio .06 [0.049-0.077] mmol-1 increase


[PMID 22517333] Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.


[PMID 22996131OA-icon.png] Monogenic models: what have the single gene disorders taught us?

GWAS snp
PMID [PMID 24244560OA-icon.png]
Trait Glycated hemoglobin levels
Title A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
Risk Allele T
P-val 6E-8
Odds Ratio .44 [0.42-0.46] unit increase
GWAS snp
PMID [PMID 24647736OA-icon.png]
Trait Glycated hemoglobin levels
Title Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Risk Allele T
P-val 2E-22
Odds Ratio .12 [0.10-0.14] unit increase


[PMID 25633883] Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis