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rs1799941

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.5 Sex Hormone-Binding Globulin levels are 0.4 standard deviations higher
(A;G) Sex Hormone-Binding Globulin levels are 0.2 standard deviations higher
(G;G) 0
ReferenceGRCh38 38.1/141
Chromosome17
Position7630105
GeneSHBG
is asnp
is mentioned by
dbSNPrs1799941
ebirs1799941
HLIrs1799941
Exacrs1799941
Varsomers1799941
Maprs1799941
PheGenIrs1799941
hapmaprs1799941
1000 genomesrs1799941
hgdprs1799941
ensemblrs1799941
gopubmedrs1799941
geneviewrs1799941
scholarrs1799941
googlers1799941
pharmgkbrs1799941
gwascentralrs1799941
openSNPrs1799941
23andMers1799941
23andMe allrs1799941
SNP Nexus

SNPshotrs1799941
SNPdbers1799941
MSV3drs1799941
GWAS Ctlgrs1799941
GMAF0.124
Max Magnitude1.5
? (A;A) (A;G) (G;G) 28
[PMID 19574343OA-icon.png] Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
OMIM182205
DescSEX HORMONE-BINDING GLOBULIN; SHBG
Variant
Relatedalso
[PMID 19679209OA-icon.png] Effects of Polymorphisms of the Sex Hormone-Binding Globulin (SHBG) Gene on Free Estradiol and Bone Mineral Density


[PMID 19933169OA-icon.png] Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes

OMIM613498
Desc
Variant
Relatedalso


[PMID 16926255] SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.


[PMID 17411440OA-icon.png] Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.


[PMID 18464913OA-icon.png] A genome-wide association study identifies protein quantitative trait loci (pQTLs).


[PMID 18628428OA-icon.png] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.


[PMID 18980759] Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect.


[PMID 19064566OA-icon.png] Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.


[PMID 19091090OA-icon.png] Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women.


[PMID 20616999OA-icon.png] Usefulness of Mendelian randomization in observational epidemiology.


[PMID 20841609OA-icon.png] Relationships of circulating sex hormone-binding globulin with metabolic traits in humans.


[PMID 21252242OA-icon.png] Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.


[PMID 21283750OA-icon.png] Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.


[PMID 21429951] Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

Sex Hormone Regulation


[PMID 24327369] Single-nucleotide polymorphism, rs1799941 in the sex hormone-binding globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study


[PMID 22936694OA-icon.png] Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.


[PMID 23001781] Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.


[PMID 25647406OA-icon.png] SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents


[PMID 25671407] A Systems Genetics Approach to Dyslipidemia in Children and Adolescents