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rs1799964

From SNPedia

Orientationplus
Stabilizedplus
Make rs1799964(C;C)
Make rs1799964(C;T)
Make rs1799964(T;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position31574531
GeneLTA, TNF
is asnp
is mentioned by
dbSNPrs1799964
ebirs1799964
HLIrs1799964
Exacrs1799964
Varsomers1799964
Maprs1799964
PheGenIrs1799964
hapmaprs1799964
1000 genomesrs1799964
hgdprs1799964
ensemblrs1799964
gopubmedrs1799964
geneviewrs1799964
scholarrs1799964
googlers1799964
pharmgkbrs1799964
gwascentralrs1799964
openSNPrs1799964
23andMers1799964
23andMe allrs1799964
SNP Nexus

SNPshotrs1799964
SNPdbers1799964
MSV3drs1799964
GWAS Ctlgrs1799964
GMAF0.2002
Max Magnitude
? (C;C) (C;T) (T;T) 28

Associated with at least one "mortality outcome" in a study of ~10,000 individuals.[PMID 18263601]

Separately, a meta-analysis of 10 case-control studies, including over 2,200 Graves' disease cases, concluded that rs1799964(C) carriers were associated with the disease.[PMID 18472000]

Neighborrs1799724
Distance174
Neighborrs1800630
Distance168
[PMID 19818126OA-icon.png] Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study




[PMID 20887379] Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients


[PMID 21995493OA-icon.png] TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy


[PMID 22666399OA-icon.png] Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study


[PMID 12509789OA-icon.png] Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.


[PMID 17216494] Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.


[PMID 17493155] Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.


[PMID 18194515OA-icon.png] Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population.


[PMID 18196539] TNF polymorphisms and prostate cancer risk.


[PMID 18620570OA-icon.png] The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.


[PMID 18635873OA-icon.png] TNF promoter polymorphisms associated with muscle phenotypes in humans.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18709160OA-icon.png] Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.


[PMID 18715339OA-icon.png] Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18811622] Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.


[PMID 19167443OA-icon.png] Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.


[PMID 19281305OA-icon.png] Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19409079OA-icon.png] Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.


[PMID 19615068OA-icon.png] The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.


[PMID 19661089OA-icon.png] Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.


[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.


[PMID 20007930OA-icon.png] A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.


[PMID 20112337OA-icon.png] Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.


[PMID 20459604OA-icon.png] Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes.


[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.


[PMID 20668555OA-icon.png] Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


GET Evidence
rs1799964
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.257812
summary



[PMID 23472126OA-icon.png] The Association between Polymorphisms in the MRPL4 and TNF-α Genes and Susceptibility to Allergic Rhinitis

GWAS snp
PMID [PMID 21102463OA-icon.png]
Trait Crohn's disease
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Risk Allele C
P-val 4E-11
Odds Ratio 1.19 [1.13-1.25]


[PMID 23840460OA-icon.png] Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population


[PMID 23870134OA-icon.png] Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma


[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects


[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria


[PMID 23380141] Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever


[PMID 24405540] [Association of TNF-1031T/C and clinical efficacy of insulin therapy in newly diagnosed type 2 diabetics]


[PMID 22464751OA-icon.png] SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.


[PMID 22711844] SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.


[PMID 22808100OA-icon.png] Functional differences exist between TNFalpha promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.


[PMID 23071570OA-icon.png] Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.


[PMID 23777929] Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.


[PMID 24935328] Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation


[PMID 25054016OA-icon.png] Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies


[PMID 25246119] Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese


[PMID 25636570] Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil


[PMID 24726621OA-icon.png] Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer


[PMID 25809685] Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population


[PMID 24896147] Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans


[PMID 26550110OA-icon.png] The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis


[PMID 27477483] TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study.