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rs1800169

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal
(A;G) 0 normal
(G;G) greater relative benefit of iloperidone to schizophrenics
ReferenceGRCh38 38.1/141
Chromosome11
Position58624028
GeneCNTF, FAM75C1
is asnp
is mentioned by
dbSNPrs1800169
ebirs1800169
HLIrs1800169
Exacrs1800169
Varsomers1800169
Maprs1800169
PheGenIrs1800169
hapmaprs1800169
1000 genomesrs1800169
hgdprs1800169
ensemblrs1800169
gopubmedrs1800169
geneviewrs1800169
scholarrs1800169
googlers1800169
pharmgkbrs1800169
gwascentralrs1800169
openSNPrs1800169
23andMers1800169
23andMe allrs1800169
SNP Nexus

SNPshotrs1800169
SNPdbers1800169
MSV3drs1800169
GWAS Ctlgrs1800169
GMAF0.1244
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1800169 is a SNP in the ciliary neurotrophic factor CNTF gene.

In a study of 417 patients with schizophrenia, 279 were treated with iloperidone while 138 were treated with placebo. Iloperidone significantly improved in 6 clinical scores versus placebo. rs1800169(G;G) homozygotes showed greater improvement with iloperidone compared to placebo for 3 of the clinical scores compared to carriers of a rs1800169(A) allele.[PMID 18303965]


[PMID 19833146] Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain



[PMID 16696750] Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women.


[PMID 20368905OA-icon.png] New atypical antipsychotics for schizophrenia: iloperidone.


GET Evidence
rs1800169
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.112474
summary