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rs1800437

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 average
(C;G) 0.72x risk for heart disease
(G;G) 0 average
ReferenceGRCh38 38.1/141
Chromosome19
Position45678134
GeneGIPR
is asnp
is mentioned by
dbSNPrs1800437
ebirs1800437
HLIrs1800437
Exacrs1800437
Varsomers1800437
Maprs1800437
PheGenIrs1800437
hapmaprs1800437
1000 genomesrs1800437
hgdprs1800437
ensemblrs1800437
gopubmedrs1800437
geneviewrs1800437
scholarrs1800437
googlers1800437
pharmgkbrs1800437
gwascentralrs1800437
openSNPrs1800437
23andMers1800437
23andMe allrs1800437
SNP Nexus

SNPshotrs1800437
SNPdbers1800437
MSV3drs1800437
GWAS Ctlgrs1800437
GMAF0.1818
Max Magnitude0
? (C;C) (C;G) (G;G) 28
SNP rs1800437, located in the coding region of the GIPR gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele. [PMID 17624916]


[PMID 19254363OA-icon.png] Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.


[PMID 20081857OA-icon.png] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.


[PMID 20516203] Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.


GET Evidence
GIPR-E354Q
aa_change Glu354Gln
aa_change_short E354Q
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.175033
summary



GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Obesity
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele G
P-val 3E-14
Odds Ratio 1.10 [NR]


[PMID 24446656] A Functional Amino Acid Substitution in the Glucose-dependent Insulinotropic Polypeptide-Receptor (GIPR) Gene is Associated with Lower Bone Mineral Density and Increased Fracture risk