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rs1800587

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) normal
(C;T) normal
(T;T) increased waist circumference and risk of disk disease
ReferenceGRCh38 38.1/141
Chromosome2
Position112785383
GeneIL1A
is asnp
is mentioned by
dbSNPrs1800587
ebirs1800587
HLIrs1800587
Exacrs1800587
Varsomers1800587
Maprs1800587
PheGenIrs1800587
hapmaprs1800587
1000 genomesrs1800587
hgdprs1800587
ensemblrs1800587
gopubmedrs1800587
geneviewrs1800587
scholarrs1800587
googlers1800587
pharmgkbrs1800587
gwascentralrs1800587
openSNPrs1800587
23andMers1800587
23andMe allrs1800587
SNP Nexus

SNPshotrs1800587
SNPdbers1800587
MSV3drs1800587
GWAS Ctlgrs1800587
GMAF0.253
Max Magnitude
? (C;C) (C;T) (T;T) 28
Rs1800587
PubMed [PMID 17471097]
Affy Probeset SNP_A-8486970
Affy Orientation same
On GW 5.0 0
Alleles A/B C/T
Ancestral C
Population Caucasian
Allele T
Case Freq.
Control Freq.
Odds Ratio Het 1.31
Odds Ratio Hom 7.87
Odds Ratio All
Disease Intervertebral disc disease (IDD)


rs1800587, also known as C-889T, is a SNP in the IL-1 alpha IL1A gene.

A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1800587(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. [PMID 18716798]

rs1800587 increases susceptibility to Intervertebral disc disease 1.31 times for (C;T) heterozygotes and 7.87 times for (T;T) homozygotes [PMID 17471097]

This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one [PMID 19158434].


[PMID 19619703OA-icon.png] Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study


[PMID 20157068] Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study


[PMID 20565898OA-icon.png] Association of IL1A and IL1B loci with primary open angle glaucoma

[PMID 20116409] The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis

[PMID 21070631OA-icon.png] The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project


[PMID 21637534OA-icon.png] Interleukin-8-251T > A, Interleukin-1?-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease


[PMID 22216303OA-icon.png] Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice


[PMID 21672595] Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis


[PMID 22285486] Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis


[PMID 21509504OA-icon.png] Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16078996OA-icon.png] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16617143OA-icon.png] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

[PMID 16719905OA-icon.png] Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16916584] Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.

[PMID 17205326] The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17459217] [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18576312OA-icon.png] A broad analysis of IL1 polymorphism and rheumatoid arthritis.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 19035492OA-icon.png] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.

[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19155622] Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19742166OA-icon.png] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.

[PMID 20196868OA-icon.png] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

[PMID 20347268] Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.

[PMID 20353565OA-icon.png] Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

[PMID 20574532OA-icon.png] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20934174] Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians.

[PMID 21205020] Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

[PMID 21385326] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.

[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.

[PMID 22341060] Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.


[PMID 23050050OA-icon.png] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up


[PMID 22723975OA-icon.png] Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study


[PMID 23216199] Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences


[PMID 24103372] Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia


[PMID 24357513] The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population


[PMID 24460370OA-icon.png] Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women


[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population


[PMID 21962386] The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.


[PMID 22623017] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.


[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.


[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 23594042] Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.


[PMID 23722873] Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.


[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population


[PMID 25758360OA-icon.png] Saving more teeth-a case for personalized care


[PMID 25865535] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia


[PMID 25902400] Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women


[PMID 26578206OA-icon.png] Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis