rs1800588
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.6 | normal HDL-C levels |
| (C;T) | 1.8 | higher HDL-C levels |
| (T;T) | 1.8 | higher HDL-C levels |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 58431476 |
| Gene | LIPC, LOC101928635 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1800588 |
| dbSNP (classic) | rs1800588 |
| ClinGen | rs1800588 |
| ebi | rs1800588 |
| HLI | rs1800588 |
| Exac | rs1800588 |
| Gnomad | rs1800588 |
| Varsome | rs1800588 |
| LitVar | rs1800588 |
| Map | rs1800588 |
| PheGenI | rs1800588 |
| Biobank | rs1800588 |
| 1000 genomes | rs1800588 |
| hgdp | rs1800588 |
| ensembl | rs1800588 |
| geneview | rs1800588 |
| scholar | rs1800588 |
| rs1800588 | |
| pharmgkb | rs1800588 |
| gwascentral | rs1800588 |
| openSNP | rs1800588 |
| 23andMe | rs1800588 |
| SNPshot | rs1800588 |
| SNPdbe | rs1800588 |
| MSV3d | rs1800588 |
| GWAS Ctlg | rs1800588 |
| GMAF | 0.3646 |
| Max Magnitude | 1.8 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1800588, also known as the -514C/T polymorphism of the LIPC gene, may influence the levels of the "good" cholestorols, the high density lipoprotein (HDL) cholesterols. Generally, the (T) allele (as published) is considered to lead to higher HDL levels.
However, high HDL cholesterol, at least when combined with another HDL raising SNP (rs708272), doesn't appear to actually protect individuals from coronary artery disease, at least based on one study of ~800 Caucasian male patients. [PMID 18164013]
| GWAS snp | |
|---|---|
| PMID | [PMID 18193044 ]
|
| Trait | HDL cholesterol |
| Title | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans |
| Risk Allele | T |
| P-val | 2.0000000000000001E-32 |
| Odds Ratio | 0.14 [0.12-0.16]% SD higher |
[PMID 19558527] Hepatic lipase promoter C-480T polymorphism (a synonym for -514C/T) is associated with serum lipids levels, but not subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study
[PMID 20075193] A genome-wide linkage scan identifies multiple QTLs for HDL cholesterol levels in families with premature CAD and MI
[PMID 19773416] A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women
[PMID 21252145] Physical Activity Modifies the Effect of LPL, LIPC and CETP Polymorphisms on HDL-C Levels and the Risk of Myocardial Infarction in Caucasian Women
[PMID 21149302] Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
[PMID 17157861] Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.
[PMID 17903299] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
[PMID 18275964] Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 18660489] Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19101670] LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19148283] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19336475] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
[PMID 19557453] beta-Carotene conversion products and their effects on adipose tissue.
[PMID 19734193] Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.
[PMID 19802338] Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.
[PMID 19822575] Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 20018036] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21347282] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
[PMID 22294764] Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.
[PMID 23262498] Impact of geneticfactorsondyslipidemia in HIV-infected patients starting antiretroviral therapy
[PMID 24426196] Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study
[PMID 22935046] A high carbohydrate diet induces the beneficial effect of the CC genotype of hepatic lipase C-514T polymorphism on the apoB100/apoAI ratio only in young Chinese males.
[PMID 23021345] Gene-diet interactions on plasma lipid levels in the Inuit population.
[PMID 23372063] Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.
[PMID 23550552] Association of hepatic lipase gene polymorphisms with hypertriglyceridemia and low high-density lipoprotein-cholesterol levels among South Indian subjects without diabetes.
[PMID 25020710] P324Circadian genes in the regulation of lipids in coronary artery disease
[PMID 25671407] A Systems Genetics Approach to Dyslipidemia in Children and Adolescents
[PMID 30041843] Genetic susceptibility to pre diabetes mellitus and related association with obesity and physical fitness components in Mexican-Mestizos.
[PMID 31910446] Genome-wide association study of metabolic syndrome in Korean populations.
