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rs1800759

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) increased risk for alcohol or drug dependence; increased agreeableness (?)
(A;C) normal; increased agreeableness (?)
(C;C) normal
ReferenceGRCh38 38.1/141
Chromosome4
Position99144358
GeneSLC3A1
is asnp
is mentioned by
dbSNPrs1800759
ebirs1800759
HLIrs1800759
Exacrs1800759
Varsomers1800759
Maprs1800759
PheGenIrs1800759
hapmaprs1800759
1000 genomesrs1800759
hgdprs1800759
ensemblrs1800759
gopubmedrs1800759
geneviewrs1800759
scholarrs1800759
googlers1800759
pharmgkbrs1800759
gwascentralrs1800759
openSNPrs1800759
23andMers1800759
23andMe allrs1800759
SNP Nexus

SNPshotrs1800759
SNPdbers1800759
MSV3drs1800759
GWAS Ctlgrs1800759
GMAF0.4605
Max Magnitude
? (A;A) (A;C) (C;C) 28
rs1800759 is a SNP in the promoter (regulatory region) of the alcohol dehydrogenase 4 (ADH4) gene.

In a study of 500+ patients with either alcohol dependence or drug dependence, rs1800759 was the most significant ADH4 SNP to be associated (in a recessive manner) with increased risk for either condition, at least in Caucasians.[PMID 16237392]

In another study, a five-factor model of personality in 243 subjects with substance dependence (175 European Americans [EAs] and 68 African Americans [AAs]), along with 296 healthy control subjects (256 EAs and 40 AAs), was conducted in association with an ADH4 SNP survey. rs1800759(A) alleles and (A;A) genotypes A/A were significantly associated with agreeableness scores.[PMID 17069770OA-icon.png]


[PMID 19925625] Cluster Headache is Associated With the Alcohol Dehydrogenase 4 (ADH4) Gene


[PMID 20626721] Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study


[PMID 22232963] [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]


[PMID 16685648OA-icon.png] Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.


[PMID 17185388OA-icon.png] Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.


[PMID 17273965OA-icon.png] Evidence of positive selection on a class I ADH locus.


[PMID 18801187OA-icon.png] Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.


[PMID 18996923OA-icon.png] Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.


[PMID 19193628OA-icon.png] ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.