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rs1800775

From SNPedia

Orientationplus
Stabilizedplus
Make rs1800775(A;A)
Make rs1800775(A;C)
Make rs1800775(C;C)
ReferenceGRCh38 38.1/141
Chromosome16
Position56961324
GeneCETP
is asnp
is mentioned by
dbSNPrs1800775
ebirs1800775
HLIrs1800775
Exacrs1800775
Varsomers1800775
Maprs1800775
PheGenIrs1800775
hapmaprs1800775
1000 genomesrs1800775
hgdprs1800775
ensemblrs1800775
gopubmedrs1800775
geneviewrs1800775
scholarrs1800775
googlers1800775
pharmgkbrs1800775
gwascentralrs1800775
openSNPrs1800775
23andMers1800775
23andMe allrs1800775
SNP Nexus

SNPshotrs1800775
SNPdbers1800775
MSV3drs1800775
GWAS Ctlgrs1800775
GMAF0.4844
Max Magnitude
? (A;A) (A;C) (C;C) 28
[PMID 19263529OA-icon.png] rs1799864(G), rs3025058(A) and rs662 were associated with increased risk, and rs1800775(A) with reduced risk of recurrent venous thromboembolism
Rs1800775
PubMed [PMID 17463246]
Affy Probeset SNP_A-2182111
Affy Orientation same
On GW 5.0 0
Alleles A/B A/C
Ancestral A
Population NEU
Allele C
Case Freq.
Control Freq. 0.44
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All -
Disease Elevated Apolipoprotein A1 (E-APOA1)


GWAS snp
PMID [PMID 18193044OA-icon.png]
Trait HDL cholesterol
Title Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Risk Allele C
P-val 1E-73
Odds Ratio 0.18 [0.16-0.20]% SD lower

[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people

OMIM118470
DescCHOLESTERYL ESTER TRANSFER PROTEIN, PLASMA; CETP
Variant
Relatedalso
OMIM612797
DescHIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS
Variant
Relatedalso


GWAS snp
PMID [PMID 20031564OA-icon.png]
Trait HDL cholesterol
Title Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis Among 18 245 Initially Healthy Women From the Women's Genome Health Study
Risk Allele A
P-val 4E-93
Odds Ratio 3.09 mg/dL increase


[PMID 19773416OA-icon.png] A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women

[PMID 21185205] The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes


[PMID 12434007OA-icon.png] SNP genotyping on a genome-wide amplified DOP-PCR template.


[PMID 12475937OA-icon.png] Association testing by DNA pooling: an effective initial screen.


[PMID 17903299OA-icon.png] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.


[PMID 18513389OA-icon.png] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.


[PMID 18549840OA-icon.png] Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.


[PMID 18637884OA-icon.png] Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19185284OA-icon.png] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.


[PMID 20018036OA-icon.png] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.


[PMID 20205905OA-icon.png] Association of repeatedly measured intermediate risk factors for complex diseases with high dimensional SNP data.


[PMID 20370913OA-icon.png] Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.


GET Evidence
rs1800775
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.499344
summary



[PMID 23351584] Common variation in cholesteryl ester transfer protein: relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio


[PMID 24283500OA-icon.png] CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population


[PMID 22715478] Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.


[PMID 23675527OA-icon.png] The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

GWAS snp
PMID [PMID 24023260OA-icon.png]
Trait Lipid traits
Title Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
Risk Allele A
P-val 3E-9
Odds Ratio .04 [0.020-0.060] unit increase
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele A
P-val 1E-11
Odds Ratio .01 [0.0091-0.0169] unit increase
GWAS snp
PMID [PMID 19936222OA-icon.png]
Trait Lipid metabolism phenotypes
Title Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val 3E-93
Odds Ratio 3.10 [NR] unit increase