|(C;C)||1.5||slightly increased risk for abdominal aortic aneurysm reported|
|(G;G)||0||common in complete genomics|
[PMID 17508011] Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.
[PMID 18257935] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)PMID 19288024] Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome.
[PMID 19435922] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
[PMID 19452524] Tumor markers and rectal cancer: support for an inflammation-related pathway
[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
[PMID 20939703] The Interleukin 6 -572 G>C (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome
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[PMID 19506792] The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort
[PMID 21833041] Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese
[PMID 22107760] Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
[PMID 22272811] Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
[PMID 22457277] A Functional Single-Nucleotide Polymorphism in Interleukin-6 Promoter is associated with Susceptibility to Tuberculosis
[PMID 22677780] Interleukin-6 -634G>C Genetic Polymorphism Is Associated with Prognosis following Surgery for Advanced Thoracic Esophageal Squamous Cell Carcinoma
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[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 15981030] Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 17003362] IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies.
[PMID 17416766] IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.
[PMID 17594514] Active and passive smoking, IL6, ESR1, and breast cancer risk.
[PMID 17694420] IL6 genotypes and colon and rectal cancer.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 17785926] Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations.
[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
[PMID 18239642] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.
[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
[PMID 18321738] Is the interleukin-6 haplotype a prognostic factor for sciatica?
[PMID 18436879] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.
[PMID 18496509] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18992263] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19230157] Immunogenetics of seasonal influenza vaccine response.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19503017] Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19729864] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
[PMID 19942621] An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
[PMID 20031584] Genetics of atherothrombotic and lacunar stroke.
[PMID 20059469] Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.
[PMID 20144192] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 20585578] The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.
[PMID 20667498] The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.
[PMID 21536090] Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.
[PMID 23088295] A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
[PMID 23569034] Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation
[PMID 23881440] Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population
[PMID 23415255] Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study
[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects
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[PMID 24371367] Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population
[PMID 24530755] Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population
[PMID 22579472] The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
[PMID 22711691] Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis.
[PMID 22714907] IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.
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[PMID 24903966] The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
[PMID 23991193] Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients
[PMID 25325233] Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population
[PMID 25648033] IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection
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[PMID 25802725] Response to the dipeptidyl peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity
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[PMID 26191285] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair
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[PMID 27476361] Genetic and clinical risk factors of root resorption associated with orthodontic treatment.