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rs1800796

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.5 slightly increased risk for abdominal aortic aneurysm reported
(C;G)
(G;G) 0 common in complete genomics
ReferenceGRCh38 38.1/141
Chromosome7
Position22726627
GeneMIR632
is asnp
is mentioned by
dbSNPrs1800796
ebirs1800796
HLIrs1800796
Exacrs1800796
Varsomers1800796
Maprs1800796
PheGenIrs1800796
hapmaprs1800796
1000 genomesrs1800796
hgdprs1800796
ensemblrs1800796
gopubmedrs1800796
geneviewrs1800796
scholarrs1800796
googlers1800796
pharmgkbrs1800796
gwascentralrs1800796
openSNPrs1800796
23andMers1800796
23andMe allrs1800796
SNP Nexus

SNPshotrs1800796
SNPdbers1800796
MSV3drs1800796
GWAS Ctlgrs1800796
GMAF0.2897
Max Magnitude1.5
? (C;C) (C;G) (G;G) 28
[PMID 17996468] rs1800796 IL-6 572G>C polymorphism (and h.211 haplotype) is associated with abdominal aortic aneurysm (AAA). The risk allele is C.

[PMID 17508011] Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.

[PMID 18257935OA-icon.png] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18449426] rs1800796 coronary artery disease 190 affected Asian Indian sibling pairs

Neighborrs1800795
Distance399
Neighborrs1800797
Distance25


[PMID 19288024] Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome.


[PMID 19435922OA-icon.png] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer

[PMID 19452524OA-icon.png] Tumor markers and rectal cancer: support for an inflammation-related pathway

[PMID 19387461OA-icon.png] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection


[PMID 20939703] The Interleukin 6 -572 G>C (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome

[PMID 20954977] Effect of IL-6 C-572G polymorphism on idiopathic membranous nephropathy risk in a han chinese population

[PMID 21137202] [Polymorphism of cytokine genes and human longevity]

[PMID 19506792] The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort


[PMID 21833041] Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese


[PMID 22107760OA-icon.png] Genetic susceptibility of intervertebral disc degeneration among young Finnish adults


[PMID 22272811OA-icon.png] Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease


[PMID 22457277OA-icon.png] A Functional Single-Nucleotide Polymorphism in Interleukin-6 Promoter is associated with Susceptibility to Tuberculosis


[PMID 22677780] Interleukin-6 -634G>C Genetic Polymorphism Is Associated with Prognosis following Surgery for Advanced Thoracic Esophageal Squamous Cell Carcinoma


[PMID 22695063OA-icon.png] Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain


[PMID 22701584OA-icon.png] IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 15981030] Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.


[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 17003362] IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies.


[PMID 17416766] IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.


[PMID 17594514OA-icon.png] Active and passive smoking, IL6, ESR1, and breast cancer risk.


[PMID 17694420OA-icon.png] IL6 genotypes and colon and rectal cancer.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 17785926] Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations.


[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.


[PMID 18239642OA-icon.png] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.


[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.


[PMID 18321738] Is the interleukin-6 haplotype a prognostic factor for sciatica?


[PMID 18436879OA-icon.png] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.


[PMID 18496509OA-icon.png] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.


[PMID 18500540OA-icon.png] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18992263OA-icon.png] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.


[PMID 19124510OA-icon.png] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19230157OA-icon.png] Immunogenetics of seasonal influenza vaccine response.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19267250OA-icon.png] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.


[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19503017OA-icon.png] Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19729864OA-icon.png] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.


[PMID 19942621OA-icon.png] An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.


[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.


[PMID 20031584OA-icon.png] Genetics of atherothrombotic and lacunar stroke.


[PMID 20059469OA-icon.png] Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.


[PMID 20144192OA-icon.png] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.


[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.


[PMID 20585578OA-icon.png] The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.


[PMID 20667498] The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.


[PMID 21536090] Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.


[PMID 23088295] A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels


[PMID 23569034] Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation


[PMID 23881440] Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population


[PMID 23415255] Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study


[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects


[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis


[PMID 24371367OA-icon.png] Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population


[PMID 24530755] Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population


[PMID 22579472] The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.


[PMID 22711691] Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis.


[PMID 22714907] IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.


[PMID 23289913] Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects.


[PMID 24903966OA-icon.png] The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy


[PMID 23991193OA-icon.png] Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients


[PMID 25325233] Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population


[PMID 25648033] IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection


[PMID 25735143] [Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction]


[PMID 25802725OA-icon.png] Response to the dipeptidyl peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity


[PMID 24782217] Role of inflammatory parameters in the susceptibility of cerebral thrombosis


[PMID 25305747OA-icon.png] IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort


[PMID 25299085] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population


[PMID 26191285OA-icon.png] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair


[PMID 26447433] IL6 gene allele-specific C/EBPα-binding activity affects the development of HBV infection through modulation of Th17/Treg balance


[PMID 25603974] Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case-control study in adults with severe osteoarthritis


[PMID 26535637] Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis


[PMID 26535651] Role of interleukin-6 gene polymorphisms in the development of prostate cancer


[PMID 26813132] [Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang].


[PMID 27476361] Genetic and clinical risk factors of root resorption associated with orthodontic treatment.