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rs1800797

From SNPedia

Orientationplus
Stabilizedplus
Make rs1800797(A;A)
Make rs1800797(A;G)
Make rs1800797(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position22726602
GeneIL6, MIR632
is asnp
is mentioned by
dbSNPrs1800797
ebirs1800797
HLIrs1800797
Exacrs1800797
Varsomers1800797
Maprs1800797
PheGenIrs1800797
hapmaprs1800797
1000 genomesrs1800797
hgdprs1800797
ensemblrs1800797
gopubmedrs1800797
geneviewrs1800797
scholarrs1800797
googlers1800797
pharmgkbrs1800797
gwascentralrs1800797
openSNPrs1800797
23andMers1800797
23andMe allrs1800797
SNP Nexus

SNPshotrs1800797
SNPdbers1800797
MSV3drs1800797
GWAS Ctlgrs1800797
GMAF0.1818
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18257935OA-icon.png] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18449426] rs1800797 coronary artery disease 190 affected Asian Indian sibling pairs

Neighborrs1800796
Distance25
[PMID 19435922OA-icon.png] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
OMIM147620
DescINTERLEUKIN 6; IL6
Variant
Relatedalso
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[PMID 18420533OA-icon.png] The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs.


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[PMID 19267250OA-icon.png] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.


[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.


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[PMID 19359268OA-icon.png] Associations of IL6 polymorphisms with lung function decline and COPD.


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[PMID 19698145OA-icon.png] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.


[PMID 20144192OA-icon.png] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.


[PMID 23050050OA-icon.png] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up


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[PMID 24974143] Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis


[PMID 25030201OA-icon.png] Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis


[PMID 25648033] IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection


[PMID 25305747OA-icon.png] IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort


[PMID 25299085] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population


[PMID 25422198] Polymorphic variation of inflammation-related genes and risk of non-Hodgkin lymphoma for Uygur and Han Chinese in Xinjiang


[PMID 26198920] Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population


[PMID 26938664] Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma.


[PMID 27502736] Identification of IL6 as a susceptibility gene for major depressive disorder.