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rs1800871

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 0.5x decreased risk for endometriosis
(C;T) 0.5x decreased risk for endometriosis
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome1
Position206773289
GeneIL10
is asnp
is mentioned by
dbSNPrs1800871
ebirs1800871
HLIrs1800871
Exacrs1800871
Varsomers1800871
Maprs1800871
PheGenIrs1800871
hapmaprs1800871
1000 genomesrs1800871
hgdprs1800871
ensemblrs1800871
gopubmedrs1800871
geneviewrs1800871
scholarrs1800871
googlers1800871
pharmgkbrs1800871
gwascentralrs1800871
openSNPrs1800871
23andMers1800871
23andMe allrs1800871
SNP Nexus

SNPshotrs1800871
SNPdbers1800871
MSV3drs1800871
GWAS Ctlgrs1800871
Merged fromRs3021097
GMAF0.4086
Max Magnitude0
? (C;C) (C;T) (T;T) 28
[PMID 18930197] rs1800871(C) carriers are associated with a reduced endometriosis risk by approximately 2x compared with the common rs1800871(T;T) genotype in a study of 196 Chinese patients.

[PMID 19210299] rs2222202 (C/T) (p=0.03) and rs1800871 (C/T) (p=0.05) showed significant allelic associations with pediatric onset Crohn's disease.

[PMID 19208551] rs1800871(T) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies.

In a study of 1,757 cases of Alzheimer's disease and 6,295 controls, an interaction was replicated between IL6 genotype rs2069837(A;A) and IL10 genotype rs1800871(C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and ApoE4 genotype. [PMID 19698145OA-icon.png]

23andMe reports that each G allele at rs1800871 is associated with 0.6x lower odds of Behçet's disease. [PMID 20622879]

Neighborrs1800896
Distance263

[PMID 19276283] Interaction between BCL2 and Interleukin-10 Gene Polymorphisms Alter Outcomes of Diffuse Large B-Cell Lymphoma following Rituximab Plus CHOP Chemotherapy


[PMID 19386798OA-icon.png] Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever

[PMID 19700159] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study


[PMID 20388104] Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications

[PMID 20509889OA-icon.png] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

GWAS snp
PMID [PMID 20622879]
Trait Behcet's disease
Title Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci
Risk Allele T
P-val 1E-14
Odds Ratio 1.45 [1.32-1.60]

[PMID 20927126] Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

[PMID 21211963] Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects


[PMID 21609779] Association of TNF-? and IL-10 polymorphisms with tuberculosis in Tunisian populations


[PMID 21917900] Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform


[PMID 22436502OA-icon.png] Interleukin-10-819 promoter polymorphism in association with gastric cancer risk


[PMID 22796266] Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16672419OA-icon.png] Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.

[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 17215862] The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17420099] Association of IL10 promoter polymorphism in Italian Alzheimer's disease.

[PMID 17592300OA-icon.png] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17929139] Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.

[PMID 17980158] Genetic variation in interleukin-10 gene and risk of oral cancer.

[PMID 18041006] Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.

[PMID 18479293OA-icon.png] Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

[PMID 18598732OA-icon.png] Vaccine immunogenetics: bedside to bench to population.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 18978339OA-icon.png] Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19409109OA-icon.png] Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

[PMID 19412539OA-icon.png] IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19604093OA-icon.png] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

[PMID 19822020OA-icon.png] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

[PMID 19852851OA-icon.png] Asthma and genes encoding components of the vitamin D pathway.

[PMID 19907653OA-icon.png] Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

[PMID 19996656] Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy.

[PMID 20112337OA-icon.png] Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.

[PMID 20299965OA-icon.png] Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.

[PMID 20525402OA-icon.png] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

[PMID 21328800] Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome.

[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.

[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

[PMID 21455338OA-icon.png] Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.

[PMID 22095765] Joint effects of Epstein-Barr virus and polymorphisms in interleukin-10 and interferon-gamma on breast cancer risk.

[PMID 22239992] Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

[PMID 22307790] Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.

[PMID 22644143] The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.


[PMID 23148667OA-icon.png] The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development


[PMID 23235789] IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample


[PMID 23574339OA-icon.png] The Interleukin 10 -819C/T Polymorphism and Cancer Risk: A HuGE Review and Meta-Analysis of 73 Studies Including 15,942 Cases and 22,336 Controls


[PMID 23668806OA-icon.png] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns


[PMID 23299779OA-icon.png] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma


[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects


[PMID 24060592] The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients


[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis


[PMID 24128120] The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis


[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria


[PMID 24269690] IL10 polymorphisms associated with Behçet's disease in Chinese Han


[PMID 24449078] Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children


[PMID 24603720OA-icon.png] Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis


[PMID 22749237OA-icon.png] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.


[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.


[PMID 23430974OA-icon.png] Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.


[PMID 23640160OA-icon.png] IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.


[PMID 24758873] Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population


[PMID 24008079OA-icon.png] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts


[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification


[PMID 25412954] Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma


[PMID 26015771OA-icon.png] Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population


[PMID 25376093OA-icon.png] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children


[PMID 26198819OA-icon.png] Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors


[PMID 26340474OA-icon.png] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis


[PMID 26400525] Association between variants of IL-8 and IL-10 genes, and efficacy of transcatheter arterial chemoembolization and subsequent prognosis in patients with liver cancer


[PMID 24684230] Analysis of interleukin-10 promoter single nucleotide polymorphisms and risk of non-Hodgkin lymphoma in a Malaysian population


[PMID 26681045] Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis.


[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.


[PMID 27228545] IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.


[PMID 27558476] The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease.


[PMID 27775822] Polymorphisms in the interleukin (IL)-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure.