Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Make rs1800872(A;A)
Make rs1800872(A;C)
Make rs1800872(C;C)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs1800872
23andMe allrs1800872
SNP Nexus

GWAS Ctlgrs1800872
Max Magnitude
? (A;A) (A;C) (C;C) 28
The IL10 C627A polymorphism in the anti-inflammatory Interleukin 10 gene decreases gene transcription.

Effect of Interleukin-10 Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma. An exploratory study with negative results.

[PMID 19208551] rs1800872(A) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies.

[PMID 19276283] Interaction between BCL2 and Interleukin-10 Gene Polymorphisms Alter Outcomes of Diffuse Large B-Cell Lymphoma following Rituximab Plus CHOP Chemotherapy

[PMID 19386798OA-icon.png] Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever

[PMID 19700159] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study

[PMID 20031567OA-icon.png] An Evaluation of Candidate Genes of Inflammation and Thrombosis in Relation to the Risk of Venous Thromboembolism: The Women's Genome Health Study

[PMID 20388104] Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications

[PMID 20509889OA-icon.png] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

[PMID 20927126] Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

[PMID 21211963] Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects

[PMID 21239167] TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer

[PMID 21609779] Association of TNF-? and IL-10 polymorphisms with tuberculosis in Tunisian populations

[PMID 21855833] Replication of Genetic Association Studies in Aortic Stenosis in Adults

[PMID 21917900] Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform

[PMID 22479352OA-icon.png] The Role of Inflammatory Pathway Genetic Variation on Maternal Metabolic Phenotypes during Pregnancy

[PMID 22594912OA-icon.png] Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

[PMID 22666399OA-icon.png] Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study

[PMID 22715992] Association of interleukin-10 gene promoter polymorphism in allergic patients

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16600026OA-icon.png] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

[PMID 16672072OA-icon.png] The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16846490OA-icon.png] Lemierre's syndrome and genetic polymorphisms: a case report.

[PMID 16959027OA-icon.png] Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.

[PMID 17215862] The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17552041] Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.

[PMID 17592300OA-icon.png] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

[PMID 17665434OA-icon.png] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17929139] Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.

[PMID 17980158] Genetic variation in interleukin-10 gene and risk of oral cancer.

[PMID 18307517OA-icon.png] Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.

[PMID 18479293OA-icon.png] Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

[PMID 18559596] Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.

[PMID 18598732OA-icon.png] Vaccine immunogenetics: bedside to bench to population.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19087313OA-icon.png] Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19264973OA-icon.png] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19347053OA-icon.png] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

[PMID 19409109OA-icon.png] Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

[PMID 19412539OA-icon.png] IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

[PMID 19458621] Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.

[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19604093OA-icon.png] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

[PMID 19852851OA-icon.png] Asthma and genes encoding components of the vitamin D pathway.

[PMID 19907653OA-icon.png] Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

[PMID 20041166OA-icon.png] Common genetic variation and the control of HIV-1 in humans.

[PMID 20196868OA-icon.png] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

[PMID 20299965OA-icon.png] Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20525402OA-icon.png] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 20725607OA-icon.png] CCL3 genotype and current depression increase risk of HIV-associated dementia.

[PMID 20737205] The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20865317] Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.

[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.

[PMID 21424183] An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.

[PMID 22239992] Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

[PMID 22372709] Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

[PMID 22644143] The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.

[PMID 23079832] Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk

[PMID 23148667OA-icon.png] The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development

[PMID 23235789] IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample

[PMID 22859398OA-icon.png] Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence

[PMID 23668806OA-icon.png] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

[PMID 23086128] Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer

[PMID 23840460OA-icon.png] Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population

[PMID 23299779OA-icon.png] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma

[PMID 23880623] Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children

[PMID 23886125] Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects

[PMID 24040186OA-icon.png] Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a chinese general population

[PMID 24060592] The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients

[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

[PMID 24128120] The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis

[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria

[PMID 24194923OA-icon.png] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study

[PMID 24327156] [Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease]

[PMID 24449078] Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children

[PMID 24603720OA-icon.png] Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis

[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.

[PMID 23133602OA-icon.png] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

[PMID 23430974OA-icon.png] Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.

[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 23640160OA-icon.png] IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.

[PMID 23790189] Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population.

[PMID 24758873] Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

[PMID 24008079OA-icon.png] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts

[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification

[PMID 24982395] Significant Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Taiwan

[PMID 23951054OA-icon.png] The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients

[PMID 25189915] Effects of Interleukin-10 Polymorphisms and Smoking on the Risk of Gastric Cancer in Taiwan

[PMID 25412954] Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma

[PMID 25735143] [Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction]

[PMID 25505294] The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection

[PMID 25503130] Interleukin-10 (IL-10) promoter genotypes are associated with lung cancer risk in Taiwan males and smokers

[PMID 26015771OA-icon.png] Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population

[PMID 25376093OA-icon.png] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children

[PMID 26198819OA-icon.png] Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors

[PMID 26340474OA-icon.png] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis

[PMID 26400525] Association between variants of IL-8 and IL-10 genes, and efficacy of transcatheter arterial chemoembolization and subsequent prognosis in patients with liver cancer

[PMID 26546526] The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults

[PMID 27210870] [Effects of IL10-592 locus of AA genotype on the incidence of aGVHD and survival after HLA-matched unrelated allogeneic hematopoietic stem cell transplantation].

[PMID 27228545] IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.

[PMID 27342690] Polymorphisms in STAT4, IL10, PSORS1C1, PTPN2 and MIR146A genes are differently associated with prognostic factors in Italian patients affected by Rheumatoid Arthritis.