|(A;A)||2||1.8x increased prostate cancer risk|
|(A;G)||2||1.6x increased prostate cancer risk|
|(G;G)||1||Normal prostate cancer risk|
This SNP is upstream of the IL10 gene, and is also known as the -1082G>A IL10 SNP.
[PMID 18440625] Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.
Dust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496). Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence ( approximately 3-fold to 39-fold increase).
A study of 258 prostate cancer cases concluded that the rs1800896(A) allele, known to result in lower levels of this anti-inflammatory cytokine, was positively associated with risk (AG vs. GG, odds ratio of 1.69, CI: 1.10-2.60; AA vs. GG, OR of 1.81, CI: 1.11-2.96).[PMID 19267370][PMID 19386798] Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever
[PMID 19700159] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study
[PMID 19760027] Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
[PMID 20388104] Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications
[PMID 20509889] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
[PMID 20927126] Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
[PMID 21211963] Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis
[PMID 21447951] Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis
[PMID 22615793] Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population
[PMID 22144535] Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study
[PMID 22715992] Association of interleukin-10 gene promoter polymorphism in allergic patients
[PMID 22825546] The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
[PMID 16600026] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
[PMID 16672072] The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.
[PMID 16672419] Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
[PMID 16842617] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
[PMID 16959027] Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.
[PMID 17215862] The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17355643] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
[PMID 17420099] Association of IL10 promoter polymorphism in Italian Alzheimer's disease.
[PMID 17552041] Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.
[PMID 17592300] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.
[PMID 17665434] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
[PMID 17690160] Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome.
[PMID 17929139] Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.
[PMID 18307517] Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.
[PMID 18479293] Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.
[PMID 18559596] Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.
[PMID 18615156] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19126646] Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19409109] Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.
[PMID 19412539] IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.
[PMID 19458621] Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19604093] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
[PMID 19673019] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
[PMID 19698145] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
[PMID 19700502] Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
[PMID 19822020] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
[PMID 19852851] Asthma and genes encoding components of the vitamin D pathway.
[PMID 19934104] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
[PMID 20047977] Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
[PMID 20299965] Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.
[PMID 20369436] Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.
[PMID 20406895] Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.
[PMID 20444268] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
[PMID 20459687] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
[PMID 20525402] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
[PMID 20737205] The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 20865317] Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.
[PMID 21030268] Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population.
[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.
[PMID 21385363] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
[PMID 21424183] An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.
[PMID 21448414] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
[PMID 21455338] Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.
[PMID 21764596] The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: a meta-analysis.
[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
[PMID 22239992] Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.
[PMID 22307790] Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.
[PMID 22372709] Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.
[PMID 22644143] The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.
[PMID 23079832] Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk
[PMID 23148667] The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development
[PMID 23235789] IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample
[PMID 22859398] Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence
[PMID 23415626] Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: A meta-analysis
[PMID 23668806] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
[PMID 23299779] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
[PMID 23013217] Analysis of polymorphisms in interleukin-10, interleukin-6, and interleukin-1 receptor antagonist in Mexican-Mestizo women with pre-eclampsia
[PMID 23880623] Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children
[PMID 22850906] Genetic factors regulating inflammation and DNA methylation associated with prostate cancer
[PMID 24060592] The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients
[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis
[PMID 24128120] The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis
[PMID 24167151] Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma
[PMID 24205307] Influence of Atg5 Mutation in SLE Depends on Functional IL-10 Genotype
[PMID 24398031] IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort
[PMID 24449078] Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children
[PMID 24603720] Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis
[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.
[PMID 23029430] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
[PMID 23133602] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.
[PMID 23391141] Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab.
[PMID 23438931] Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.
[PMID 23640160] IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.
[PMID 23736221] The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.
[PMID 23777929] Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.
[PMID 23857017] Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.
[PMID 24758873] Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population
[PMID 24801553] Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms
[PMID 24008079] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts
[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification
[PMID 24982395] Significant Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Taiwan
[PMID 25189915] Effects of Interleukin-10 Polymorphisms and Smoking on the Risk of Gastric Cancer in Taiwan
[PMID 25412954] Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma
[PMID 25503130] Interleukin-10 (IL-10) promoter genotypes are associated with lung cancer risk in Taiwan males and smokers
[PMID 26015771] Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population
[PMID 26142334] IL-10 gene polymorphism and influence of chemotherapy on cytokine plasma levels in childhood acute lymphoblastic leukemia patients: IL-10 polymorphism and plasma levels in leukemia patients
[PMID 26340474] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis
[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal
[PMID 24684230] Analysis of interleukin-10 promoter single nucleotide polymorphisms and risk of non-Hodgkin lymphoma in a Malaysian population
[PMID 25566937] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis
[PMID 26546526] The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults
[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.
[PMID 27228545] IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.
[PMID 27363685] Role of Interleukin-10 (-1082A/G) gene polymorphism with the risk of ischemic stroke: a meta-analysis.
[PMID 27558476] The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease.