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rs1800896

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2 1.8x increased prostate cancer risk
(A;G) 2 1.6x increased prostate cancer risk
(G;G) 1 Normal prostate cancer risk
ReferenceGRCh38 38.1/141
Chromosome1
Position206773552
GeneIL10
is asnp
is mentioned by
dbSNPrs1800896
ebirs1800896
HLIrs1800896
Exacrs1800896
Varsomers1800896
Maprs1800896
PheGenIrs1800896
hapmaprs1800896
1000 genomesrs1800896
hgdprs1800896
ensemblrs1800896
gopubmedrs1800896
geneviewrs1800896
scholarrs1800896
googlers1800896
pharmgkbrs1800896
gwascentralrs1800896
openSNPrs1800896
23andMers1800896
23andMe allrs1800896
SNP Nexus

SNPshotrs1800896
SNPdbers1800896
MSV3drs1800896
GWAS Ctlgrs1800896
GMAF0.3026
Max Magnitude2
? (A;A) (A;G) (G;G) 28

This SNP is upstream of the IL10 gene, and is also known as the -1082G>A IL10 SNP.

[PMID 18440625] Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.

Dust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496). Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence ( approximately 3-fold to 39-fold increase).

A study of 258 prostate cancer cases concluded that the rs1800896(A) allele, known to result in lower levels of this anti-inflammatory cytokine, was positively associated with risk (AG vs. GG, odds ratio of 1.69, CI: 1.10-2.60; AA vs. GG, OR of 1.81, CI: 1.11-2.96).[PMID 19267370OA-icon.png]

Neighborrs1800871
Distance263
[PMID 19386798OA-icon.png] Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever

[PMID 19700159] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study

[PMID 19760027OA-icon.png] Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer


[PMID 20388104] Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications

[PMID 20509889OA-icon.png] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

[PMID 20927126] Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

[PMID 21211963] Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis


[PMID 21447951] Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis


[PMID 22615793OA-icon.png] Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population


[PMID 22144535OA-icon.png] Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study


[PMID 22715992] Association of interleukin-10 gene promoter polymorphism in allergic patients


[PMID 22825546] The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.


[PMID 16600026OA-icon.png] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.


[PMID 16672072OA-icon.png] The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.


[PMID 16672419OA-icon.png] Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.


[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).


[PMID 16842617OA-icon.png] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.


[PMID 16959027OA-icon.png] Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.


[PMID 17215862] The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.


[PMID 17420099] Association of IL10 promoter polymorphism in Italian Alzheimer's disease.


[PMID 17552041] Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.


[PMID 17592300OA-icon.png] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.


[PMID 17665434OA-icon.png] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.


[PMID 17690160OA-icon.png] Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome.


[PMID 17929139] Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.


[PMID 18307517OA-icon.png] Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.


[PMID 18479293OA-icon.png] Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.


[PMID 18559596] Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.


[PMID 18615156OA-icon.png] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.


[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19126646OA-icon.png] Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19409109OA-icon.png] Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.


[PMID 19412539OA-icon.png] IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.


[PMID 19458621] Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 19604093OA-icon.png] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.


[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.


[PMID 19698145OA-icon.png] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.


[PMID 19700502] Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.


[PMID 19822020OA-icon.png] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.


[PMID 19852851OA-icon.png] Asthma and genes encoding components of the vitamin D pathway.


[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.


[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.


[PMID 20047977OA-icon.png] Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.


[PMID 20196868OA-icon.png] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.


[PMID 20299965OA-icon.png] Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.


[PMID 20369436] Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.


[PMID 20406895OA-icon.png] Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.


[PMID 20444268OA-icon.png] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.


[PMID 20459687OA-icon.png] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.


[PMID 20525402OA-icon.png] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.


[PMID 20737205] The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 20865317] Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.


[PMID 21030268] Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population.


[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.


[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.


[PMID 21424183] An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.


[PMID 21448414OA-icon.png] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.


[PMID 21455338OA-icon.png] Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.


[PMID 21764596] The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: a meta-analysis.


[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.


[PMID 22239992] Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.


[PMID 22307790] Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.


[PMID 22372709] Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.


[PMID 22644143] The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.


[PMID 23079832] Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk


[PMID 23148667OA-icon.png] The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development


[PMID 23235789] IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample


[PMID 22859398OA-icon.png] Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence


[PMID 23415626] Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: A meta-analysis


[PMID 23668806OA-icon.png] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns


[PMID 23299779OA-icon.png] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma


[PMID 23013217OA-icon.png] Analysis of polymorphisms in interleukin-10, interleukin-6, and interleukin-1 receptor antagonist in Mexican-Mestizo women with pre-eclampsia


[PMID 23880623] Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children


[PMID 22850906] Genetic factors regulating inflammation and DNA methylation associated with prostate cancer


[PMID 24060592] The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients


[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis


[PMID 24128120] The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis


[PMID 24167151] Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma


[PMID 24205307OA-icon.png] Influence of Atg5 Mutation in SLE Depends on Functional IL-10 Genotype


[PMID 24398031OA-icon.png] IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort


[PMID 24449078] Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children


[PMID 24603720OA-icon.png] Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis


[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.


[PMID 23133602OA-icon.png] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.


[PMID 23391141] Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab.


[PMID 23438931OA-icon.png] Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.


[PMID 23640160OA-icon.png] IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.


[PMID 23736221OA-icon.png] The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.


[PMID 23777929] Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.


[PMID 23857017] Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.


[PMID 24758873] Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population


[PMID 24801553OA-icon.png] Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms


[PMID 24008079OA-icon.png] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts


[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification


[PMID 24982395] Significant Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Taiwan


[PMID 25189915] Effects of Interleukin-10 Polymorphisms and Smoking on the Risk of Gastric Cancer in Taiwan


[PMID 25412954] Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma


[PMID 25503130] Interleukin-10 (IL-10) promoter genotypes are associated with lung cancer risk in Taiwan males and smokers


[PMID 26015771OA-icon.png] Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population


[PMID 26142334] IL-10 gene polymorphism and influence of chemotherapy on cytokine plasma levels in childhood acute lymphoblastic leukemia patients: IL-10 polymorphism and plasma levels in leukemia patients


[PMID 26340474OA-icon.png] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis


[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal


[PMID 24684230] Analysis of interleukin-10 promoter single nucleotide polymorphisms and risk of non-Hodgkin lymphoma in a Malaysian population


[PMID 25566937OA-icon.png] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis


[PMID 26546526] The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults


[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.


[PMID 27228545] IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.


[PMID 27363685] Role of Interleukin-10 (-1082A/G) gene polymorphism with the risk of ischemic stroke: a meta-analysis.


[PMID 27558476] The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease.