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rs1805010

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in clinvar
Make rs1805010(A;G)
Make rs1805010(G;G)
ReferenceGRCh38 38.1/141
Chromosome16
Position27344882
GeneIL4R
is asnp
is mentioned by
dbSNPrs1805010
ebirs1805010
HLIrs1805010
Exacrs1805010
Varsomers1805010
Maprs1805010
PheGenIrs1805010
hapmaprs1805010
1000 genomesrs1805010
hgdprs1805010
ensemblrs1805010
gopubmedrs1805010
geneviewrs1805010
scholarrs1805010
googlers1805010
pharmgkbrs1805010
gwascentralrs1805010
openSNPrs1805010
23andMers1805010
23andMe allrs1805010
SNP Nexus

SNPshotrs1805010
SNPdbers1805010
MSV3drs1805010
GWAS Ctlgrs1805010
GMAF0.4656
Max Magnitude0
? (A;A) (A;G) (G;G) 28

[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial


[PMID 19796199] Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease

OMIM147781
Desc
Variant0002
Relatedalso


[PMID 22119518] Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population


ClinVar
Risk rs1805010(G;G)
Alt rs1805010(G;G)
Reference rs1805010(A;A)
Significance Other
Disease Atopy Acquired immunodeficiency syndrome
Variation info
Gene IL4R
CLNDBN Atopy, resistance to Acquired immunodeficiency syndrome, slow progression to
Reversed 0
HGVS NC_000016.9:g.27356203A>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000015776.4, RCV000015777.4,



[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18625055OA-icon.png] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.


[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19759553OA-icon.png] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.


[PMID 19956098OA-icon.png] Association analysis of SNPs in the IL4R locus with type I diabetes.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.


[PMID 20298583OA-icon.png] Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.


GET Evidence
IL4R-I75V
aa_change Ile75Val
aa_change_short I75V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.46979
summary



[PMID 23299779OA-icon.png] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma


[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma


[PMID 22484276] Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: following up on Taiwan's neonatal hepatitis B immunization program.


[PMID 24782180] Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis Are Associated With a Genetic Variant in the IL4R Gene, rs1805010


[PMID 25785117OA-icon.png] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis


[PMID 26426602] Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study