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rs1805015

From SNPedia

Orientationplus
Stabilizedplus
Make rs1805015(C;C)
Make rs1805015(C;T)
Make rs1805015(T;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position27362859
GeneIL4R
is asnp
is mentioned by
dbSNPrs1805015
ebirs1805015
HLIrs1805015
Exacrs1805015
Varsomers1805015
Maprs1805015
PheGenIrs1805015
hapmaprs1805015
1000 genomesrs1805015
hgdprs1805015
ensemblrs1805015
gopubmedrs1805015
geneviewrs1805015
scholarrs1805015
googlers1805015
pharmgkbrs1805015
gwascentralrs1805015
openSNPrs1805015
23andMers1805015
23andMe allrs1805015
SNP Nexus

SNPshotrs1805015
SNPdbers1805015
MSV3drs1805015
GWAS Ctlgrs1805015
Merged fromRs17513769
GMAF0.2098
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 18927306OA-icon.png] among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R rs1805016 and rs1805015 TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)
Neighborrs1801275
Distance220
Neighborrs17513769
Distance1


[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

OMIM147781
Desc
Variant0003
Relatedalso


[PMID 22119518] Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population


[PMID 21867552OA-icon.png] Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites


ClinVar
Risk rs1805015(C;C)
Alt rs1805015(C;C)
Reference rs1805015(T;T)
Significance Other
Disease Atopy
Variation info
Gene IL4R
CLNDBN Atopy, resistance to
Reversed 0
HGVS NC_000016.9:g.27374180T>C
CLNSRC OMIM Allelic Variant
CLNACC RCV000015778.25,



[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16024651OA-icon.png] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.


[PMID 16600026OA-icon.png] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.


[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.


[PMID 18256354OA-icon.png] IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.


[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19264973OA-icon.png] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19956098OA-icon.png] Association analysis of SNPs in the IL4R locus with type I diabetes.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.


[PMID 20219689] Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.


[PMID 20298583OA-icon.png] Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.


[PMID 20401335OA-icon.png] Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.


[PMID 20459687OA-icon.png] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.


GET Evidence
IL4R-S503P
aa_change Ser503Pro
aa_change_short S503P
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.23192
summary



[PMID 23480403] Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study


[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma


[PMID 23979976] Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk


[PMID 22902050OA-icon.png] Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.


[PMID 23462527] IL4R and IL13 polymorphic variants and development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to HBV vaccination or infection.


[PMID 23663310OA-icon.png] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.


[PMID 25785117OA-icon.png] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis


[PMID 26448013OA-icon.png] High Incidence of Malaria Along the Sino-Burmese Border Is Associated With Polymorphisms of CR1, IL-1A, IL-4R, IL-4, NOS, and TNF, But Not With G6PD Deficiency