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rs1805016

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0
Make rs1805016(G;G)
Make rs1805016(G;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position27363606
GeneIL4R
is asnp
is mentioned by
dbSNPrs1805016
ebirs1805016
HLIrs1805016
Exacrs1805016
Varsomers1805016
Maprs1805016
PheGenIrs1805016
hapmaprs1805016
1000 genomesrs1805016
hgdprs1805016
ensemblrs1805016
gopubmedrs1805016
geneviewrs1805016
scholarrs1805016
googlers1805016
pharmgkbrs1805016
gwascentralrs1805016
openSNPrs1805016
23andMers1805016
23andMe allrs1805016
SNP Nexus

SNPshotrs1805016
SNPdbers1805016
MSV3drs1805016
GWAS Ctlgrs1805016
GMAF0.118
Max Magnitude0
? (G;G) (G;T) (T;T) 28
[PMID 18927306OA-icon.png] among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R rs1805016 and rs1805015 TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)
Neighborrs1801275
Distance527
[PMID 16600026OA-icon.png] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.


[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19956098OA-icon.png] Association analysis of SNPs in the IL4R locus with type I diabetes.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


GET Evidence
IL4R-S752A
aa_change Ser752Ala
aa_change_short S752A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.141755
summary