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rs1805097

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) twice as likely to reach extreme old age?
(A;G) normal
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome13
Position109782884
GeneIRS2
is asnp
is mentioned by
dbSNPrs1805097
ebirs1805097
HLIrs1805097
Exacrs1805097
Varsomers1805097
Maprs1805097
PheGenIrs1805097
hapmaprs1805097
1000 genomesrs1805097
hgdprs1805097
ensemblrs1805097
gopubmedrs1805097
geneviewrs1805097
scholarrs1805097
googlers1805097
pharmgkbrs1805097
gwascentralrs1805097
openSNPrs1805097
23andMers1805097
23andMe allrs1805097
SNP Nexus

SNPshotrs1805097
SNPdbers1805097
MSV3drs1805097
GWAS Ctlgrs1805097
GMAF0.2971
Max Magnitude
rs1805097, also known as Gly1057Asp, is a SNP in the insulin receptor substrate-2 IRS2 gene. The rs1805097(G) allele is associated with the Gly, and the (A) allele with Asp.

A longevity study categorizing 677 participants as either long-lived (i.e. over 85 years old) or not (less than 85) somehow concluded that rs1805097(A;A) individuals were about twice as likely to reach extreme old age (odds ratio 2.03, CI:1.39-2.99, p = .0003).[PMID 19887537]

OMIM600797
DescDIABETES, TYPE II, SUSCEPTIBILITY TO
Variant0001
Relatedalso


[PMID 19818665] Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm


ClinVar
Risk rs1805097(A;A)
Alt rs1805097(A;A)
Reference rs1805097(G;G)
Significance Other
Disease DIABETES
Variation info
Gene IRS2
CLNDBN DIABETES, TYPE II, SUSCEPTIBILITY TO
Reversed 1
HGVS NC_000013.10:g.110435231C>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000009368.2,



[PMID 18398040OA-icon.png] Transcription factor 7-like 2 polymorphism and colon cancer.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18611262OA-icon.png] Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.


[PMID 18992263OA-icon.png] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.


[PMID 19124510OA-icon.png] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.


GET Evidence
IRS2-G1057D
aa_change Gly1057Asp
aa_change_short G1057D
impact protective
qualified_impact Low clinical importance, Uncertain protective
overall_frequency 0.232615
summary a.k.a Gly1057Asp, insulin receptor substrate-2 IRS2. The rs1805097(G) allele is associated with the Gly, and the (A) allele with Asp. A longevity study concluded that rs1805097(A;A) individuals were about twice as likely to live over 85 y/o (odds ratio 2.03, CI:1.39-2.99, p = .0003).