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rs1805127

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common in clinvar
(A;G) 1.4 slight (1.4x) increase in risk for atrial fibrillation
Make rs1805127(G;G)
ReferenceGRCh38 38.1/141
Chromosome21
Position34449523
GeneKCNE1
is asnp
is mentioned by
dbSNPrs1805127
ebirs1805127
HLIrs1805127
Exacrs1805127
Varsomers1805127
Maprs1805127
PheGenIrs1805127
hapmaprs1805127
1000 genomesrs1805127
hgdprs1805127
ensemblrs1805127
gopubmedrs1805127
geneviewrs1805127
scholarrs1805127
googlers1805127
pharmgkbrs1805127
gwascentralrs1805127
openSNPrs1805127
23andMers1805127
23andMe allrs1805127
SNP Nexus

SNPshotrs1805127
SNPdbers1805127
MSV3drs1805127
GWAS Ctlgrs1805127
Merged fromRs17846179
GMAF0.3315
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28
ClinVar
Risk rs1805127(G;G)
Alt rs1805127(G;G)
Reference rs1805127(A;A)
Significance Non-pathogenic
Disease not specified not provided Hearing loss
Variation info
Gene KCNE1
CLNDBN not specified not provided Hearing loss, noise-induced, susceptibility to
Reversed 1
HGVS NC_000021.8:g.35821821T>C
CLNSRC ClinVar GeneDx
CLNACC RCV000035351.3, RCV000119063.5, RCV000171811.2,



[PMID 17227789] The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study.


[PMID 17534376OA-icon.png] Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects.


[PMID 18520591OA-icon.png] Sequence variants in host cell factor C1 are associated with Meniere's disease.


[PMID 18674739] Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.


[PMID 19019189OA-icon.png] Common candidate gene variants are associated with QT interval duration in the general population.


[PMID 19660109OA-icon.png] Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes.


[PMID 21811988] [Association of rs1805127 polymorphism of KCNE1 gene with atrial fibrillation in Uigur population of Xinjiang].


[PMID 17210] [Carbogen therapy of acute cochlear disorders].


[PMID 12402336] DHPLC analysis of potassium ion channel genes in congenital long QT syndrome.


[PMID 14760488] Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.


[PMID 16487223OA-icon.png] Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore.


[PMID 17597962] Mutation screening in KCNQ1, HERG, KCNE1, KCNE2 and SCN5A genes in a long QT syndrome family.


[PMID 18426444] Single nucleotide polymorphisms and haplotype of four genes encoding cardiac ion channels in Chinese and their association with arrhythmia.


[PMID 23874724OA-icon.png] KCNE1 rs1805127 Polymorphism Increases the Risk of Atrial Fibrillation: A Meta-Analysis of 10 Studies


[PMID 22934933] A replication study on proposed candidate genes in Meniere's disease, and a review of the current status of genetic studies.


[PMID 23020083OA-icon.png] Association of KCNE1 genetic polymorphisms with atrial fibrillation in a Chinese Han population.