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rs1815739(T;T)

From SNPedia

Impaired muscle performance. Likely endurance athlete.
Is agenotype
ofrs1815739
GeneACTN3
Chromosome11
Position66,560,624
Merged fromRs2228325
mentionedby
Magnitude2.2
Geno Mag Summary
(C;C) 2.2 Better performing muscles. Likely sprinter.
(C;T) 2.1 Mix of muscle types. Likely sprinter.
(T;T) 2.2 Impaired muscle performance. Likely endurance athlete.

Early reports such as [PMID 18043716] suggested this is under-represented in elite strength and sprint athletes, consistent with previous reports of impaired muscle performance. However this is more common in endurance athletes. This SNP makes fast-twitch muscle fibers completely unable to produce alpha-actinin-3. In 2016 a larger attempt at replication failed to find any signficant result