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rs1837253

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal/common in clinvar
(C;T) 2.2 reduced risk (0.84x) for late-onset (adult) asthma
(T;T) 2.8 reduced risk (0.73) for late-onset (adult) asthma
ReferenceGRCh38 38.1/141
Chromosome5
Position111066174
GeneTSLP
is asnp
is mentioned by
dbSNPrs1837253
ebirs1837253
HLIrs1837253
Exacrs1837253
Varsomers1837253
Maprs1837253
PheGenIrs1837253
hapmaprs1837253
1000 genomesrs1837253
hgdprs1837253
ensemblrs1837253
gopubmedrs1837253
geneviewrs1837253
scholarrs1837253
googlers1837253
pharmgkbrs1837253
gwascentralrs1837253
openSNPrs1837253
23andMers1837253
23andMe allrs1837253
SNP Nexus

SNPshotrs1837253
SNPdbers1837253
MSV3drs1837253
GWAS Ctlgrs1837253
GMAF0.3627
Max Magnitude2.8
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs1837253 is a SNP found a bit upstream of the thymic stromal lymphopoietin TSLP gene on chromosome 5. The TSLP protein plays a role in inflammation of cells in the trachea and alveoli therefore may have a causative role in certain types of asthma.

The rs1837253(T) allele has been found to reduce the risk of developing late-onset (adult) asthma in several studies, and it is recognized by the CPMC Study as one they report to their participants.

? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 21804548OA-icon.png]
Trait
Title Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Risk Allele C
P-val 1E-16
Odds Ratio 1.1700 [1.13-1.22]
GWAS snp
PMID [PMID 21804549OA-icon.png]
Trait
Title Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Risk Allele
P-val 1E-14
Odds Ratio None None


[PMID 19539984] A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness.


[PMID 20560908OA-icon.png] TSLP polymorphisms are associated with asthma in a sex-specific fashion.


[PMID 21244681OA-icon.png] Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma.

GWAS snp
PMID [PMID 24388013OA-icon.png]
Trait Asthma and hay fever
Title Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
Risk Allele C
P-val 1E-9
Odds Ratio 1.17 [1.12-1.24]


[PMID 25700684] Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study