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rs185386680

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common/normal
(A;G) 2.2 carrier of one HLA-B*38:02:01 allele; avoid thioamide drugs
Make rs185386680(G;G)
ReferenceGRCh38.p2 38.2/146
Chromosome6
Position31207153
is asnp
is mentioned by
dbSNPrs185386680
ebirs185386680
HLIrs185386680
Exacrs185386680
Varsomers185386680
Maprs185386680
PheGenIrs185386680
hapmaprs185386680
1000 genomesrs185386680
hgdprs185386680
ensemblrs185386680
gopubmedrs185386680
geneviewrs185386680
scholarrs185386680
googlers185386680
pharmgkbrs185386680
gwascentralrs185386680
openSNPrs185386680
23andMers185386680
23andMe allrs185386680
SNP Nexus

SNPshotrs185386680
SNPdbers185386680
MSV3drs185386680
GWAS Ctlgrs185386680
Max Magnitude2.2

rs185386680(G) appears to be in complete linkage disequilibrium with the HLA-B*38:02:01 allele, and can therefore be used as a marker for it.[PMID 26599303]

The HLA-B*38:02:01 allele is associated with carbimazole/methimazole-induced agranulocytosis (OR=265.5, CI: 27.9-2528, p=2.5x10-e14), but not associated with propylthiouracil, so screening for the risk allele may be useful in preventing agranulocytosis in hyperthyroid patients potentially being treated with thioamides antithyroid-drugs, such as thioacetamide, methimazole, or carbimazole.[PMID 26599303]