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rs1859345

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) slightly earlier age at menarche
(C;T) normal
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome5
Position137111731
GeneSPOCK1
is asnp
is mentioned by
dbSNPrs1859345
ebirs1859345
HLIrs1859345
Exacrs1859345
Varsomers1859345
Maprs1859345
PheGenIrs1859345
hapmaprs1859345
1000 genomesrs1859345
hgdprs1859345
ensemblrs1859345
gopubmedrs1859345
geneviewrs1859345
scholarrs1859345
googlers1859345
pharmgkbrs1859345
gwascentralrs1859345
openSNPrs1859345
23andMers1859345
23andMe allrs1859345
SNP Nexus

SNPshotrs1859345
SNPdbers1859345
MSV3drs1859345
GWAS Ctlgrs1859345
GMAF0.2241
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs1859345 is a SNP in the - get ready - "sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1" SPOCK1 gene.

A study of 477 Caucasian women, followed up by replication studies in another ~1,600 and also 1,300+ Chinese women, found that several linked SNPs in the SPOCK1 gene are associated with age at menarche. rs1859345 replicated across all groups studied (p < 10e-3), with the minor (C) allele associated with a (slightly) earlier age at menarche.[PMID 19282985OA-icon.png]