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rs187116

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1 among patients with gastric cancer, risk for more aggressive form?
(C;T) 1 among patients with gastric cancer, risk for more aggressive form?
(T;T) 0
ReferenceGRCh38 38.1/141
Chromosome11
Position35144253
GeneCD44
is asnp
is mentioned by
dbSNPrs187116
dbSNP (classic)rs187116
ClinGenrs187116
ebirs187116
HLIrs187116
Exacrs187116
Gnomadrs187116
Varsomers187116
LitVarrs187116
Maprs187116
PheGenIrs187116
Biobankrs187116
1000 genomesrs187116
hgdprs187116
ensemblrs187116
geneviewrs187116
scholarrs187116
googlers187116
pharmgkbrs187116
gwascentralrs187116
openSNPrs187116
23andMers187116
SNPshotrs187116
SNPdbers187116
MSV3drs187116
GWAS Ctlgrs187116
GMAF0.4683
Max Magnitude1
? (C;C) (C;T) (T;T) 28


rs187116, also known as +4883G>A, is a SNP in the CD44 gene.

A presentation at the 2010 American Society of Clinical Oncology meeting based on ~100 patients reported this SNP as being significantly associated with more aggressive gastric cancer. In dbSNP orientation, the risk allele is rs187116(C); patients carrying at least one rs187116(C) had a significantly shorter median time-to-recurrence (TTR) of 2.1 years compared to 7.0 years TTR for rs187116(T;T) patients (p = 0.036, log-rank test).[1]


[PMID 21105049OA-icon.png] Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.


[PMID 22710270OA-icon.png] Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.


[PMID 28149016OA-icon.png] Cluster of Differentiation 44 (CD44) Gene Variants: A Putative Cancer Stem Cell Marker in Risk Prediction of Bladder Cancer in North Indian Population.


[PMID 31450925OA-icon.png] Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand.