Have questions? Visit https://www.reddit.com/r/SNPedia

rs187116

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1 among patients with gastric cancer, risk for more aggressive form?
(C;T) 1 among patients with gastric cancer, risk for more aggressive form?
(T;T) 0
ReferenceGRCh38 38.1/141
Chromosome11
Position35144253
GeneCD44
is asnp
is mentioned by
dbSNPrs187116
ebirs187116
HLIrs187116
Exacrs187116
Varsomers187116
Maprs187116
PheGenIrs187116
hapmaprs187116
1000 genomesrs187116
hgdprs187116
ensemblrs187116
gopubmedrs187116
geneviewrs187116
scholarrs187116
googlers187116
pharmgkbrs187116
gwascentralrs187116
openSNPrs187116
23andMers187116
23andMe allrs187116
SNP Nexus

SNPshotrs187116
SNPdbers187116
MSV3drs187116
GWAS Ctlgrs187116
GMAF0.4683
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs187116, also known as +4883G>A, is a SNP in the CD44 gene.

A presentation at the 2010 American Society of Clinical Oncology meeting based on ~100 patients reported this SNP as being significantly associated with more aggressive gastric cancer. In dbSNP orientation, the risk allele is rs187116(C); patients carrying at least one rs187116(C) had a significantly shorter median time-to-recurrence (TTR) of 2.1 years compared to 7.0 years TTR for rs187116(T;T) patients (p = 0.036, log-rank test).[1]


[PMID 21105049OA-icon.png] Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.


[PMID 22710270OA-icon.png] Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.