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rs1876828

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common in clinvar
Make rs1876828(A;A)
Make rs1876828(A;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position45834159
GeneCRHR1
is asnp
is mentioned by
dbSNPrs1876828
ebirs1876828
HLIrs1876828
Exacrs1876828
Varsomers1876828
Maprs1876828
PheGenIrs1876828
hapmaprs1876828
1000 genomesrs1876828
hgdprs1876828
ensemblrs1876828
gopubmedrs1876828
geneviewrs1876828
scholarrs1876828
googlers1876828
pharmgkbrs1876828
gwascentralrs1876828
openSNPrs1876828
23andMers1876828
23andMe allrs1876828
SNP Nexus

SNPshotrs1876828
SNPdbers1876828
MSV3drs1876828
GWAS Ctlgrs1876828
GMAF0.1162
Max Magnitude0
[PMID 18565889] The G allele at the rs1876828 SNP was associated with lower z scores (P = .02) in males but tended to have the opposite association in females (P = .09). CRHR1 polymorphisms may impact the risk of bone density deficits in patients treated with corticosteroids and antimetabolites in a sex-specific manner.



[PMID 15365580] Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.


[PMID 19750552OA-icon.png] Risk and resilience: genetic and environmental influences on development of the stress response.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 22641026OA-icon.png] Predicting inhaled corticosteroid response in asthma with two associated SNPs.


GET Evidence
rs1876828
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.111111
summary



[PMID 23726670] Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum


ClinVar
Risk rs1876828(A;A)
Alt rs1876828(A;A)
Reference rs1876828(G;G)
Significance Drug-response
Disease triamcinolone response - Efficacy corticosteroids response - Efficacy fluticasone propionate response - Efficacy fluticasone/salmeterol response - Efficacy budesonide response - Efficacy
Variation info
Gene CRHR1 MGC57346-CRHR1
CLNDBN triamcinolone response - Efficacy corticosteroids response - Efficacy fluticasone propionate response - Efficacy fluticasone/salmeterol response - Efficacy budesonide response - Efficacy
Reversed 1
HGVS NC_000017.10:g.43911525C>T
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211182.1, RCV000211194.1, RCV000211279.1, RCV000211365.1, RCV000211373.1,