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rs1889018

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) normal
(C;T) 1.12x increased risk for T2D
(T;T) 0 1.12x increased risk for T2D
ReferenceGRCh38 38.1/141
Chromosome17
Position17831426
GeneSREBF1
is asnp
is mentioned by
dbSNPrs1889018
ebirs1889018
HLIrs1889018
Exacrs1889018
Varsomers1889018
Maprs1889018
PheGenIrs1889018
hapmaprs1889018
1000 genomesrs1889018
hgdprs1889018
ensemblrs1889018
gopubmedrs1889018
geneviewrs1889018
scholarrs1889018
googlers1889018
pharmgkbrs1889018
gwascentralrs1889018
openSNPrs1889018
23andMers1889018
23andMe allrs1889018
SNP Nexus

SNPshotrs1889018
SNPdbers1889018
MSV3drs1889018
GWAS Ctlgrs1889018
GMAF0.3214
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs1889018 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.12 (CI: 1.01-1.24, p=0.04) for the minor (risk) allele, rs1889018(T). This allele was also associated with a surrogate measure of insulin sensitivity (p=0.03).[PMID 18192539]


[PMID 17019602OA-icon.png] Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.