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rs1948

From SNPedia

Orientationminus
Stabilizedplus
Make rs1948(C;C)
Make rs1948(C;T)
Make rs1948(T;T)
ReferenceGRCh38 38.1/142
Chromosome15
Position78625057
GeneCHRNB4
is asnp
is mentioned by
dbSNPrs1948
ebirs1948
HLIrs1948
Exacrs1948
Varsomers1948
Maprs1948
PheGenIrs1948
hapmaprs1948
1000 genomesrs1948
hgdprs1948
ensemblrs1948
gopubmedrs1948
geneviewrs1948
scholarrs1948
googlers1948
pharmgkbrs1948
gwascentralrs1948
openSNPrs1948
23andMers1948
23andMe allrs1948
SNP Nexus

SNPshotrs1948
SNPdbers1948
MSV3drs1948
GWAS Ctlgrs1948
GMAF0.3177
Max Magnitude
? (C;C) (C;T) (T;T) 28

The (C;C) genotype (as published) of rs1948 was calculated to represent a hazard ratio of 1.29 (CI: 1.01-1.63) for initiation of tobacco and alcohol use at an earlier age than average. A linked SNP also in the A5A3B4 gene, rs8023462, showed similiar association. [PMID 18163978OA-icon.png]


[PMID 17373692OA-icon.png] No evidence for association between 19 cholinergic genes and bipolar disorder.


[PMID 18165968OA-icon.png] Identification of pharmacogenetic markers in smoking cessation therapy.


[PMID 18571741OA-icon.png] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.


[PMID 18957677OA-icon.png] The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.


[PMID 19029397OA-icon.png] Nicotinic receptor gene variants influence susceptibility to heavy smoking.


[PMID 19492010OA-icon.png] The genetic components of alcohol and nicotine co-addiction: from genes to behavior.


[PMID 22241830OA-icon.png] Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.


[PMID 23872218OA-icon.png] Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors


[PMID 22945651OA-icon.png] Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.