Have questions? Visit https://www.reddit.com/r/SNPedia

rs1983132

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(C;T) 3 2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos
(T;T) 3 2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos
ReferenceGRCh38 38.1/141
Chromosome4
Position177298634
is asnp
is mentioned by
dbSNPrs1983132
ebirs1983132
HLIrs1983132
Exacrs1983132
Varsomers1983132
Maprs1983132
PheGenIrs1983132
hapmaprs1983132
1000 genomesrs1983132
hgdprs1983132
ensemblrs1983132
gopubmedrs1983132
geneviewrs1983132
scholarrs1983132
googlers1983132
pharmgkbrs1983132
gwascentralrs1983132
openSNPrs1983132
23andMers1983132
23andMe allrs1983132
SNP Nexus

SNPshotrs1983132
SNPdbers1983132
MSV3drs1983132
GWAS Ctlgrs1983132
GMAF0.219
Max Magnitude3
? (C;C) (C;T) (T;T) 28
rs1983132 is a SNP in the NEIL3 gene on ch 4, which encodes a glycosylase that can initiate base excision repair.

A study of pesticide use and SNPs in ~800 prostate cancer cases revealed a significant association between men with either a rs1983132(C;T) or (T;T) genotype exposed to the pesticide fonofos and disease risk. The odds ratios and for low and high pesticide use versus no use were 1.65 (CI:0.91-3.01) and 3.25 (CI:1.78-5.92), respectively, whereas fonofos was not associated with prostate cancer risk among men with a rs1983132(C;C) genotype.[PMID 21810555OA-icon.png]