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rs198358

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) normal
(A;G) lower blood pressure
(G;G) lower blood pressure
ReferenceGRCh38 38.1/141
Chromosome1
Position11844019
GeneCLCN6, NPPA-AS1
is asnp
is mentioned by
dbSNPrs198358
ebirs198358
HLIrs198358
Exacrs198358
Varsomers198358
Maprs198358
PheGenIrs198358
hapmaprs198358
1000 genomesrs198358
hgdprs198358
ensemblrs198358
gopubmedrs198358
geneviewrs198358
scholarrs198358
googlers198358
pharmgkbrs198358
gwascentralrs198358
openSNPrs198358
23andMers198358
23andMe allrs198358
SNP Nexus

SNPshotrs198358
SNPdbers198358
MSV3drs198358
GWAS Ctlgrs198358
GMAF0.2351
Max Magnitude
? (A;A) (A;G) (G;G) 28

A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower blood pressure and hypertension were associated with SNPs rs17376328(A), rs5068, rs198358(C), rs632793(G) [PMID 19219041OA-icon.png]23andMe blog

[PMID 19326473OA-icon.png] Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

[PMID 19439027OA-icon.png] Dissecting complex traits: recent advances in hypertension genomics.

[PMID 20031578OA-icon.png] Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.

[PMID 20407391] Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study.

[PMID 21276798] Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.

[PMID 22504314OA-icon.png] Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.


[PMID 23315043] Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study