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rs198389

From SNPedia

Orientationplus
Stabilizedplus
Make rs198389(A;A)
Make rs198389(A;G)
Make rs198389(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position11859214
GeneNPPB
is asnp
is mentioned by
dbSNPrs198389
ebirs198389
HLIrs198389
Exacrs198389
Varsomers198389
Maprs198389
PheGenIrs198389
hapmaprs198389
1000 genomesrs198389
hgdprs198389
ensemblrs198389
gopubmedrs198389
geneviewrs198389
scholarrs198389
googlers198389
pharmgkbrs198389
gwascentralrs198389
openSNPrs198389
23andMers198389
23andMe allrs198389
SNP Nexus

SNPshotrs198389
SNPdbers198389
MSV3drs198389
GWAS Ctlgrs198389
GMAF0.3173
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 17719005] Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF) rs198389 (T-381C), plasma BNP levels among the three genotypic categories, i.e., 2189 homozygous T-allele carriers (BNP 26.4+/-0.6pg/ml), 697 heterozygous carriers (35.0+/-1.1pg/ml), and 52 homozygous C-allele carriers (46.0+/-4.1pg/ml) indicated a co-dominant effect of the minor C-allele on elevating plasma BNP levels (P<0.0001)


[PMID 19326473OA-icon.png] Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

[PMID 19377085] The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49,279 subjects


[PMID 19413180] SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension


[PMID 19631175OA-icon.png] Natriuretic peptides in the diagnosis and management of chronic heart failure.


[PMID 21273288OA-icon.png] Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.


[PMID 21276798] Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.


[PMID 21364112OA-icon.png] The effect of the brain-type natriuretic peptide single-nucleotide polymorphism rs198389 on test characteristics of common assays.


[PMID 23315043] Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study


[PMID 23288489OA-icon.png] Prospective evaluation of B-type natriuretic peptide concentrations and the risk of type 2 diabetes in women.


[PMID 25934190] Examination of the brain natriuretic peptide rs198389 single-nucleotide polymorphism on type 2 diabetes mellitus and related phenotypes in an Algerian population


[PMID 26908625] Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome.