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rs198977

From SNPedia

Orientationplus
Stabilizedplus
Make rs198977(C;C)
Make rs198977(C;T)
Make rs198977(T;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position50878521
GeneKLK2
is asnp
is mentioned by
dbSNPrs198977
ebirs198977
HLIrs198977
Exacrs198977
Varsomers198977
Maprs198977
PheGenIrs198977
hapmaprs198977
1000 genomesrs198977
hgdprs198977
ensemblrs198977
gopubmedrs198977
geneviewrs198977
scholarrs198977
googlers198977
pharmgkbrs198977
gwascentralrs198977
openSNPrs198977
23andMers198977
23andMe allrs198977
SNP Nexus

SNPshotrs198977
SNPdbers198977
MSV3drs198977
GWAS Ctlgrs198977
GMAF0.2893
Max Magnitude
? (C;C) (C;T) (T;T) 28
In 2014 study "Human kallikrein-2 gene and protein expression predicts prostate cancer at repeat biopsy" rs198977 T allele was found associated with prostate cancer at repeat biopsy with 1.8 odds ratio (95% CI: 1.04-3.13, p = 0.049). High serum hK2 level (> 0.163 ng/mL average in the study) correlated with rs198977, and combined they predicted prostate cancer with OR 3.77 (95% CI: 1.94-7.32, p <0.0001). However, addition of these factors did not significantly improve existing baseline model with age, ethnic background, PSA, DRE, past histology, prostate volume, and family history as risk indicators. This study was conducted with quite selective sample group of 941 patients and is likely not applicable to general population, however it does convincingly back up the association found in earlier studies.


[PMID 20424135OA-icon.png] Blood Biomarker Levels to Aid Discovery of Cancer-Related Single-Nucleotide Polymorphisms: Kallikreins and Prostate Cancer


[PMID 21178268OA-icon.png] Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer


[PMID 17085659] Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.


[PMID 20514297OA-icon.png] 2010 CUA Abstracts.


GET Evidence
KLK2-R250W
aa_change Arg250Trp
aa_change_short R250W
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.309351
summary



[PMID 24270797OA-icon.png] Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men