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rs2010963

From SNPedia

Orientationplus
Stabilizedplus
Make rs2010963(C;C)
Make rs2010963(C;G)
Make rs2010963(G;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position43770613
GeneVEGFA
is asnp
is mentioned by
dbSNPrs2010963
ebirs2010963
HLIrs2010963
Exacrs2010963
Varsomers2010963
Maprs2010963
PheGenIrs2010963
hapmaprs2010963
1000 genomesrs2010963
hgdprs2010963
ensemblrs2010963
gopubmedrs2010963
geneviewrs2010963
scholarrs2010963
googlers2010963
pharmgkbrs2010963
gwascentralrs2010963
openSNPrs2010963
23andMers2010963
23andMe allrs2010963
SNP Nexus

SNPshotrs2010963
SNPdbers2010963
MSV3drs2010963
GWAS Ctlgrs2010963
GMAF0.3434
Max Magnitude

[PMID 19308252OA-icon.png] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation


[PMID 19761764] Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population

[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer

[PMID 19875757] Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy


[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation


[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population


[PMID 20209496] Possible association between polymorphisms of human vascular endothelial growth factor a gene and susceptibility to glioma in a Chinese population


[PMID 20489684] Vascular Endothelial Growth Factor Polymorphisms and Extent of Coronary Atherosclerosis in Chinese Population With Advanced Coronary Artery Disease

[PMID 20210775] The role of vascular endothelial growth factor gene as the genetic marker of atherothrombotic disorders and in the gene therapy of coronary artery disease

[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration

[PMID 20847577] Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort



[PMID 21316969] Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population

OMIM192240
Desc
Variant0001
Relatedalso


[PMID 19653005] The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes


[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study


[PMID 22129133] VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma


[PMID 22209952] Vascular endothelial growth factor (VEGF) +405 C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran


[PMID 22258388] Association of NOS2 and potential effect of VEGF, IL6, CCL2 and IL1RN polymorphisms and haplotypes on susceptibility to GCA--a simultaneous study of 130 potentially functional SNPs in 14 candidate genes


[PMID 22162628OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes


[PMID 22521084] Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.


[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients

[PMID 15338501] Vascular endothelial growth factor gene polymorphisms in Behcet's disease.

[PMID 16142870] A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.

[PMID 16216669] Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.

[PMID 16395752] Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.

[PMID 16613616OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

[PMID 16645995] Vascular endothelial growth factor gene haplotypes in Kawasaki disease.

[PMID 16685110] Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.

[PMID 17204151OA-icon.png] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

[PMID 17319747OA-icon.png] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17625508] VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.

[PMID 17917691OA-icon.png] Genetic markers and biomarkers for age-related macular degeneration.

[PMID 17983459] Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

[PMID 18281657] VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

[PMID 18378209] Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.

[PMID 18650217] Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

[PMID 18780893OA-icon.png] Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 19026761OA-icon.png] Molecular pathology of age-related macular degeneration.

[PMID 19041064] Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

[PMID 19089753] Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.

[PMID 19438866OA-icon.png] Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.

[PMID 19566948OA-icon.png] Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

[PMID 19584152OA-icon.png] Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

[PMID 19587357OA-icon.png] A systematic meta-analysis of genetic association studies for diabetic retinopathy.

[PMID 19603096OA-icon.png] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

[PMID 19628492] Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.

[PMID 19755511OA-icon.png] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

[PMID 19787077OA-icon.png] Association of vascular endothelial growth factor polymorphisms with asthma in Tunisian children.

[PMID 19835575OA-icon.png] The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

[PMID 20140301] VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20444917] Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.

[PMID 20621071] Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease.

[PMID 20706635OA-icon.png] Human genetics of diabetic retinopathy: current perspectives.

[PMID 20832104] Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival.

[PMID 21245770] Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis.

[PMID 21347390OA-icon.png] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

[PMID 21362767] Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

[PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.

[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

[PMID 22139971] Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

[PMID 22307787] Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.

[PMID 22320189OA-icon.png] Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

[PMID 22427559] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes.

[PMID 22429695] Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.


[PMID 23073296] VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population


GET Evidence
rs2010963
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.630435
summary



[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage


[PMID 22776467] Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes


[PMID 23490417] Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans


[PMID 23511629OA-icon.png] VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib


[PMID 23673188] Vascular Endothelial Growth Factor gene (VEGFA) polymorphisms may serve as a prognostic factors for recurrent depressive disorder development


[PMID 23794399] VEGFA, FLT1, KDR and colorectal cancer: Assessment of disease risk, tumor molecular phenotype, and survival


[PMID 23848209] Vascular endothelial growth factor A (VEGFA) polymorphisms in Chinese patients with rheumatoid arthritis


[PMID 23880405] Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population


[PMID 24039754OA-icon.png] The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer


[PMID 24321896] Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension


[PMID 24353087] Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer


[PMID 22865486] Interaction among nitric oxide (NO)-related genes in migraine susceptibility.


[PMID 22915033] The C allele of -634G/C polymorphism in the VEGFA gene is associated with increased VEGFA gene expression in human retinal tissue.


[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.


[PMID 23007311] VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.


[PMID 23061744] Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.


[PMID 23064377OA-icon.png] Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis.


[PMID 23353010] VEGF -634G>C polymorphism and diabetic retinopathy risk: a meta-analysis.


[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.


[PMID 23553563] VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.


[PMID 23644986] Genetic polymorphisms of vascular endothelial growth factor and risk for retinopathy of prematurity in South of Iran.


[PMID 24868559OA-icon.png] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies


[PMID 24652518OA-icon.png] VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT)


[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study


[PMID 25239121] Variants in angiogenesis-related genes and the risk of clear cell renal cell carcinoma


ClinVar
Risk rs2010963(G;G)
Alt rs2010963(G;G)
Reference rs2010963(C;C)
Significance Other
Disease Microvascular complications of diabetes 1
Variation info
Gene VEGFA
CLNDBN Microvascular complications of diabetes 1
Reversed 0
HGVS NC_000006.11:g.43738350C>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000013007.2,



[PMID 25713884] Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism


[PMID 24945674OA-icon.png] Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma


[PMID 25834741OA-icon.png] Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes


[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population


[PMID 26002049] Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril


[PMID 26075076OA-icon.png] Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis


[PMID 26254278OA-icon.png] Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy


[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers


[PMID 26486233] Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level


[PMID 24971577OA-icon.png] Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia


[PMID 25714003] Association of VEGFA gene polymorphisms and VEGFA plasma levels with spontaneous preterm birth


[PMID 26535684] VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head


[PMID 27116510] Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.


[PMID 27704620] The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease.