Have questions? Visit https://www.reddit.com/r/SNPedia

rs2011077(A;G)

From SNPedia

In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer
Is agenotype
ofrs2011077
GeneFGFR4
Chromosome5
Position177,094,455
mentionedby
ReputeBad
Geno Mag Summary
(A;A) 1 Normal risk of developing prostate cancer, BPH, and metastatic prostate cancer
(A;G) In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer
(G;G) 3 In Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancer

For the rs2011077 polymorphism, a significant increased risk of prostate cancer was found in men with the GG genotype (aOR = 6.260, 95% CI = 3.152–12.433, p < 0.001) or the GA genotype (aOR = 2.497, 95% CI = 1.717–3.630, p < 0.001) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of prostate cancer with a gene dosage effect (aOR = 2.500, 95% CI = 1.871–3.339, p < 0.001). As for BPH, a significantly increased risk was found in the GG genotype (aOR = 3.033, 95% CI = 1.352–6.807, p = 0.007) and the GA genotype (aOR = 1.700, 95% CI = 1.077–2.683, p = 0.023) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of BPH with a gene dosage effect (aOR = 1.724, 95% CI = 1.218–2.441, p = 0.002).