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rs2014307

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) increased risk of age-related macular degeneration
Make rs2014307(A;C)
Make rs2014307(C;C)
ReferenceGRCh38 38.1/142
Chromosome10
Position122458116
GeneARMS2
is asnp
is mentioned by
dbSNPrs2014307
ebirs2014307
HLIrs2014307
Exacrs2014307
Varsomers2014307
Maprs2014307
PheGenIrs2014307
hapmaprs2014307
1000 genomesrs2014307
hgdprs2014307
ensemblrs2014307
gopubmedrs2014307
geneviewrs2014307
scholarrs2014307
googlers2014307
pharmgkbrs2014307
gwascentralrs2014307
openSNPrs2014307
23andMers2014307
23andMe allrs2014307
SNP Nexus

SNPshotrs2014307
SNPdbers2014307
MSV3drs2014307
GWAS Ctlgrs2014307
GMAF0.3641
Max Magnitude
? (A;A) (A;C) (C;C) 28
news

rs572515 was the most significantly associated with AMD risk (P <10-6).

rs9288410 and rs2014307 (PLEKHA1/HTRA1) on 10q26 were significantly associated with AMD status (P= .03 and P <10-6 respectively). After controlling for smoking history, gender and age, the most significant gene-gene interaction appears to be between rs10801575 (CFH) and rs2014307 (PLEKHA1/HTRA1) (P <10-11).


[PMID 18541031OA-icon.png] The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.