|| increased risk of age-related macular degeneration
|?|| (A;A) (A;C) (C;C) ||28|
rs572515 was the most significantly associated with AMD risk (P <10-6).
rs9288410 and rs2014307 (PLEKHA1/HTRA1) on 10q26 were significantly associated with AMD status (P= .03 and P <10-6 respectively). After controlling for smoking history, gender and age, the most significant gene-gene interaction appears to be between rs10801575 (CFH) and rs2014307 (PLEKHA1/HTRA1) (P <10-11).
[PMID 18541031] The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.