rs2036527
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.1 | Tend not to be a heavy smoker |
| (C;T) | 1 | Average tendency to become a heavy smoker |
| (T;T) | 2.1 | Tend to be a heavy smoker |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 78559273 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2036527 |
| dbSNP (classic) | rs2036527 |
| ClinGen | rs2036527 |
| ebi | rs2036527 |
| HLI | rs2036527 |
| Exac | rs2036527 |
| Gnomad | rs2036527 |
| Varsome | rs2036527 |
| LitVar | rs2036527 |
| Map | rs2036527 |
| PheGenI | rs2036527 |
| Biobank | rs2036527 |
| 1000 genomes | rs2036527 |
| hgdp | rs2036527 |
| ensembl | rs2036527 |
| geneview | rs2036527 |
| scholar | rs2036527 |
| rs2036527 | |
| pharmgkb | rs2036527 |
| gwascentral | rs2036527 |
| openSNP | rs2036527 |
| 23andMe | rs2036527 |
| SNPshot | rs2036527 |
| SNPdbe | rs2036527 |
| MSV3d | rs2036527 |
| GWAS Ctlg | rs2036527 |
| GMAF | 0.2126 |
| Max Magnitude | 2.1 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 20554942
] Nicotinic Acetylcholine Receptor Region on Chromosome 15q25 and Lung Cancer Risk Among African Americans: A Case-Control Study
| GWAS snp | |
|---|---|
| PMID | [PMID 21946350]
|
| Trait | |
| Title | Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. |
| Risk Allele | G |
| P-val | 7E-7 |
| Odds Ratio | 0.0260 [0.016-0.036] unit increase |
[PMID 22832964] Genome-wide meta-analyses of smoking behaviors in African Americans
[PMID 17373692] No evidence for association between 19 cholinergic genes and bipolar disorder.
[PMID 18519524] Variants in nicotinic receptors and risk for nicotine dependence.
[PMID 18759969] In search of causal variants: refining disease association signals using cross-population contrasts.
[PMID 19029397] Nicotinic receptor gene variants influence susceptibility to heavy smoking.
[PMID 19247474] Genome-wide and candidate gene association study of cigarette smoking behaviors.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
[PMID 22241830] Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
[PMID 22945651] Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
[PMID 26981579] Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
