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rs2048327

From SNPedia

Orientationminus
Stabilizedminus
Make rs2048327(A;A)
Make rs2048327(A;G)
Make rs2048327(G;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position160442500
GeneSLC22A3
is asnp
is mentioned by
dbSNPrs2048327
ebirs2048327
HLIrs2048327
Exacrs2048327
Varsomers2048327
Maprs2048327
PheGenIrs2048327
hapmaprs2048327
1000 genomesrs2048327
hgdprs2048327
ensemblrs2048327
gopubmedrs2048327
geneviewrs2048327
scholarrs2048327
googlers2048327
pharmgkbrs2048327
gwascentralrs2048327
openSNPrs2048327
23andMers2048327
23andMe allrs2048327
SNP Nexus

SNPshotrs2048327
SNPdbers2048327
MSV3drs2048327
GWAS Ctlgrs2048327
GMAF0.3223
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele C
P-val 1E-6
Odds Ratio 1.07 [1.05-1.10]
GWAS snp
PMID [PMID 19198611]
Trait Coronary artery disease
Title Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
Risk Allele
P-val 4E-15 (CCTC)
Odds Ratio 1.82 [1.57-2.12]
GWAS snp
PMID [PMID 19198611]
Trait Coronary artery disease
Title Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
Risk Allele
P-val 1E-9 (CTTG)
Odds Ratio 1.2 [1.13-1.28]


[PMID 23202125OA-icon.png] Large-scale association analysis identifies new risk loci for coronary artery disease.

[PMID 20429798] Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension.

[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 19591196] Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

GET Evidence
rs2048327
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.28125
summary



[PMID 27893421] PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population.