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rs2066827

From SNPedia

Orientationplus
Stabilizedplus
Make rs2066827(G;G)
Make rs2066827(G;T)
Make rs2066827(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position12718165
GeneCDKN1B, LOC101929220
is asnp
is mentioned by
dbSNPrs2066827
ebirs2066827
HLIrs2066827
Exacrs2066827
Varsomers2066827
Maprs2066827
PheGenIrs2066827
hapmaprs2066827
1000 genomesrs2066827
hgdprs2066827
ensemblrs2066827
gopubmedrs2066827
geneviewrs2066827
scholarrs2066827
googlers2066827
pharmgkbrs2066827
gwascentralrs2066827
openSNPrs2066827
23andMers2066827
23andMe allrs2066827
SNP Nexus

SNPshotrs2066827
SNPdbers2066827
MSV3drs2066827
GWAS Ctlgrs2066827
GMAF0.2952
Max Magnitude
? (G;G) (G;T) (T;T) 28

[PMID 20075119] Allelic variant at -79 (C>T) in CDKNIB (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels


[PMID 17409409] Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.


[PMID 17459456OA-icon.png] A common variant of the p16(INK4a) genetic region is associated with physical function in older people.


[PMID 18174243OA-icon.png] Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.


[PMID 18281541OA-icon.png] Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival.


[PMID 18389087OA-icon.png] Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.


[PMID 18507837OA-icon.png] Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.


[PMID 18543099] No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.


[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.


[PMID 19258477OA-icon.png] Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.


[PMID 19543528OA-icon.png] Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.


[PMID 19667240] p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.


GET Evidence
CDKN1B-V109G
aa_change Val109Gly
aa_change_short V109G
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.393409
summary



[PMID 24920291] Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations


[PMID 25565272] Polymorphisms of cell cycle control genes influence the development of sporadic medullary thyroid carcinoma


[PMID 26579796OA-icon.png] Genetic Association Between CDKN1B rs2066827 Polymorphism and Susceptibility to Cancer